PDF(Pubmed)
Abstract：
This review explains the strategies behind genomics, proteomics, metabolomics, metallomics and isotopolomics approaches and their applicability to written artefacts. The respective sub-chapters give an insight into the analytical procedure and the conclusions drawn from such analyses. A distinction is made between information that can be obtained from the materials used in the respective manuscript and meta-information that cannot be obtained from the manuscript itself, but from residues of organisms such as bacteria or the authors and readers. In addition, various sampling techniques are discussed in particular, which pose a special challenge in manuscripts. The focus is on high-resolution, non-targeted strategies that can be used to extract the maximum amount of information about ancient objects. The combination of the various omics disciplines (panomics) especially offers potential added value in terms of the best possible interpretations of the data received. The information obtained can be used to understand the production of ancient artefacts, to gain impressions of former living conditions, to prove their authenticity, to assess whether there is a toxic hazard in handling the manuscripts, and to be able to determine appropriate measures for their conservation and restoration.
摘要：
这篇综述解释了基因组学背后的策略，蛋白质组学，代谢组学，金属组学和同位素组学方法及其对书面人工制品的适用性。各子章节对分析程序和从此类分析中得出的结论进行了深入的了解。区分了可以从相应手稿中使用的材料中获得的信息和无法从手稿本身获得的元信息，而是来自细菌或作者和读者等生物体的残留物。此外,特别讨论了各种采样技术，这对手稿构成了特殊的挑战。重点是高分辨率，非目标策略，可用于提取有关古代物体的最大信息量。各种组学学科（panomics）的组合尤其在对所接收数据的最佳解释方面提供了潜在的附加值。获得的信息可用于了解古代文物的生产，为了获得以前生活条件的印象，为了证明它们的真实性,评估处理手稿是否有有毒危险，并能够确定适当的措施来保护和恢复它们。
