PDF(Pubmed)
Abstract：
Skin cancer is one of the cancers that registers the highest number of new cases annually. Among all forms of skin cancer, melanoma is the most invasive and deadliest. The resistance of this form of cancer to conventional treatments has led to the employment of alternative/complementary therapeutic approaches. Photodynamic therapy (PDT) appears to be a promising alternative to overcome the resistance of melanoma to conventional therapies. PDT is a non-invasive therapeutic procedure in which highly reactive oxygen species (ROS) are generated upon excitation of a photosensitizer (PS) when subjected to visible light of an adequate wavelength, resulting in the death of cancer cells. In this work, inspired by the efficacy of tetrapyrrolic macrocycles to act as PS against tumor cells, we report the photophysical characterization and biological assays of isobacteriochlorins and their corresponding chlorins and porphyrins against melanoma cancer cells through a photodynamic process. The non-tumoral L929 fibroblast murine cell line was used as the control. The results show that the choice of adequate tetrapyrrolic macrocycle-based PS can be modulated to improve the performance of PDT.
摘要：
皮肤癌是每年新病例最多的癌症之一。在所有形式的皮肤癌中，黑色素瘤是最具侵袭性和最致命的。这种形式的癌症对常规治疗的抗性导致采用替代/补充治疗方法。光动力疗法(PDT)似乎是克服黑素瘤对常规疗法的抗性的有希望的替代方案。PDT是一种非侵入性治疗方法，其中当光敏剂（PS）受到适当波长的可见光激发时，会产生高活性氧（ROS）。导致癌细胞死亡。在这项工作中,受到四吡咯大环化合物作为PS对抗肿瘤细胞的功效的启发，我们报道了通过光动力学过程对黑素瘤癌细胞的等细菌氯及其相应的氯和卟啉的光物理表征和生物学分析。使用非肿瘤L929成纤维细胞鼠细胞系作为对照。结果表明，可以调节选择适当的四吡咯大环PS以提高PDT的性能。
