PDF(Pubmed)
Abstract：
C-terminal domain nuclear envelope phosphatase 1 (CTDNEP1, formerly Dullard) is a member of the newly emerging protein phosphatases and has been recognized in neuronal cell tissues in amphibians. It contains the phosphatase domain in the C-terminal, and the sequences are conserved in various taxa of organisms. CTDNEP1 has several roles in novel biological activities such as neural tube development in embryos, nuclear membrane biogenesis, regulation of bone morphogenetic protein signaling, and suppression of aggressive medulloblastoma. The three-dimensional structure of CTDNEP1 and the detailed action mechanisms of CTDNEP1\'s functions have yet to be determined for several reasons. Therefore, CTDNEP1 is a protein phosphatase of interest due to recent exciting and essential works. In this short review, we summarize the presented biological roles, possible substrates, interacting proteins, and research prospects of CTDNEP1.
摘要：
C末端结构域核包膜磷酸酶1（CTDNEP1，前身为Dullard）是新出现的蛋白磷酸酶的成员，已在两栖动物的神经元细胞组织中被识别。它在C末端含有磷酸酶结构域，这些序列在各种生物类群中都是保守的。CTDNEP1在胚胎神经管发育等新型生物活动中具有多种作用，核膜生物发生，骨形态发生蛋白信号的调节，和抑制侵袭性髓母细胞瘤。CTDNEP1的三维结构和CTDNEP1功能的详细作用机制尚未确定，原因有几个。因此,CTDNEP1是一种感兴趣的蛋白磷酸酶，由于最近令人兴奋和必要的工作。在这篇简短的评论中，我们总结了所呈现的生物学作用，可能的底物，相互作用的蛋白质，CTDNEP1的研究前景。
