PDF(Pubmed)
Abstract：
The steady-state redox status is physiologically important and therefore homeostatically maintained. Changes in the status result in signaling (eustress) or oxidative damage (distress). Oxidative stress (OS) is a hard-to-quantitate term that can be estimated only based on different biomarkers. Clinical application of OS, particularly for selective antioxidant treatment of people under oxidative stress, requires quantitative evaluation and is limited by the lack of universal biomarkers to describe it. Furthermore, different antioxidants have different effects on the redox state. Hence, as long as we do not have the possibility to determine and quantify OS, therapeutic interventions by the \"identify-and-treat\" approach cannot be assessed and are, therefore, not likely to be the basis for selective preventive measures against oxidative damage.
摘要：
稳态氧化还原状态在生理上很重要，因此可以保持稳态。状态的变化会导致信号传导（正常应激）或氧化损伤（痛苦）。氧化应激（OS）是一个难以定量的术语，只能根据不同的生物标志物进行评估。OS的临床应用,特别是对处于氧化应激状态的人进行选择性抗氧化治疗，需要定量评估，并且由于缺乏通用的生物标志物来描述它而受到限制。此外，不同的抗氧化剂对氧化还原状态有不同的影响。因此，只要我们没有确定和量化操作系统的可能性，“识别和治疗”方法的治疗性干预措施无法评估，因此,不可能是选择性预防氧化损伤的基础。
