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Abstract：
Interleukin 10 (IL-10) plays a role in inflammation and cell-type responses. The anti-SS-A/Ro antibody contributes to leucopenia, and cutaneous and neonatal lupus.
To evaluate the association between serum IL-10 levels and autoantibodies, disease activity and organ involvement in systemic lupus erythematosus (SLE) patients.
We studied 200 SLE patients and 50 controls. We analyzed organ involvement, disease activity, serum IL-10 and interleukin-6 (IL-6) levels, and antinuclear and antiphospholipid antibody profiles.
Serum IL-10 and IL-6 levels were higher in SLE patients than in controls (all p < 0.00001). Serum IL-10 levels were positively correlated with IL-6 (p < 0.00001), CRP (p < 0.00001), fibrinogen (p = 0.003), and ESR (p < 0.00001), and negatively correlated with hemoglobin (p = 0.0004) and lymphocytes (p = 0.01). Serum IL-6 levels were positively correlated with CRP (p < 0.00001), fibrinogen (p = 0.001), and ESR (p < 0.00001); and negatively correlated with hemoglobin (p = 0.008) and lymphocytes (p = 0.03). Elevated serum IL-10 levels were associated with an increased risk of anti-SS-A/Ro antibody positivity (p = 0.03). Elevated serum IL-6 levels were associated with an increased risk of heart (p = 0.007) and lung (p = 0.04) involvement.
In SLE patients, increased serum IL-10 levels were associated with increased disease activity and risk of anti-SS-A/Ro antibody positivity.
To evaluate the association between serum IL-10 levels and autoantibodies, disease activity and organ involvement in systemic lupus erythematosus (SLE) patients.
We studied 200 SLE patients and 50 controls. We analyzed organ involvement, disease activity, serum IL-10 and interleukin-6 (IL-6) levels, and antinuclear and antiphospholipid antibody profiles.
Serum IL-10 and IL-6 levels were higher in SLE patients than in controls (all p < 0.00001). Serum IL-10 levels were positively correlated with IL-6 (p < 0.00001), CRP (p < 0.00001), fibrinogen (p = 0.003), and ESR (p < 0.00001), and negatively correlated with hemoglobin (p = 0.0004) and lymphocytes (p = 0.01). Serum IL-6 levels were positively correlated with CRP (p < 0.00001), fibrinogen (p = 0.001), and ESR (p < 0.00001); and negatively correlated with hemoglobin (p = 0.008) and lymphocytes (p = 0.03). Elevated serum IL-10 levels were associated with an increased risk of anti-SS-A/Ro antibody positivity (p = 0.03). Elevated serum IL-6 levels were associated with an increased risk of heart (p = 0.007) and lung (p = 0.04) involvement.
In SLE patients, increased serum IL-10 levels were associated with increased disease activity and risk of anti-SS-A/Ro antibody positivity.
摘要：
白细胞介素10(IL-10)在炎症和细胞型反应中起作用。抗SS-A/Ro抗体有助于白细胞减少症，皮肤和新生儿狼疮.
目的：为了评估血清IL-10水平与自身抗体之间的关系，系统性红斑狼疮（SLE）患者的疾病活动和器官受累。
方法：我们研究了200例SLE患者和50例对照。我们分析了器官受累,疾病活动,血清IL-10和白介素-6（IL-6）水平，以及抗核和抗磷脂抗体谱。
结果：SLE患者的血清IL-10和IL-6水平高于对照组（所有p<0.00001）。血清IL-10水平与IL-6呈正相关(p<0.00001),CRP（p<0.00001），纤维蛋白原（p=0.003），和ESR（p<0.00001），与血红蛋白(p=0.0004)和淋巴细胞(p=0.01)呈负相关。血清IL-6水平与CRP呈正相关(p<0.00001),纤维蛋白原（p=0.001），和ESR（p<0.00001）；与血红蛋白（p=0.008）和淋巴细胞（p=0.03）呈负相关。血清IL-10水平升高与抗SS-A/Ro抗体阳性风险增加相关(p=0.03)。血清IL-6水平升高与心脏（p=0.007）和肺（p=0.04）受累风险增加相关。
结论：在SLE患者中，血清IL-10水平升高与疾病活动性增加和抗SS-A/Ro抗体阳性风险相关.
目的：为了评估血清IL-10水平与自身抗体之间的关系，系统性红斑狼疮（SLE）患者的疾病活动和器官受累。
方法：我们研究了200例SLE患者和50例对照。我们分析了器官受累,疾病活动,血清IL-10和白介素-6（IL-6）水平，以及抗核和抗磷脂抗体谱。
结果：SLE患者的血清IL-10和IL-6水平高于对照组（所有p<0.00001）。血清IL-10水平与IL-6呈正相关(p<0.00001),CRP（p<0.00001），纤维蛋白原（p=0.003），和ESR（p<0.00001），与血红蛋白(p=0.0004)和淋巴细胞(p=0.01)呈负相关。血清IL-6水平与CRP呈正相关(p<0.00001),纤维蛋白原（p=0.001），和ESR（p<0.00001）；与血红蛋白（p=0.008）和淋巴细胞（p=0.03）呈负相关。血清IL-10水平升高与抗SS-A/Ro抗体阳性风险增加相关(p=0.03)。血清IL-6水平升高与心脏（p=0.007）和肺（p=0.04）受累风险增加相关。
结论：在SLE患者中，血清IL-10水平升高与疾病活动性增加和抗SS-A/Ro抗体阳性风险相关.
