PDF(Pubmed)
Abstract：
This study aimed to analyze the fatty acid content in human milk and to find its relationship with the growth velocity of preterm infants. Mature milk samples from 15 mothers of preterm infants were collected from three different hospitals, followed by lipid extraction, fatty acid methylation, and finally gas chromatography analysis to determine the fatty acids composition. The average total lipid content was 3.61 ± 1.57 g/100 mL with the following classes of fatty acids: saturated fatty acids 43.54 ± 11.16%, unsaturated fatty acids 52.22 ± 10.89%, in which monounsaturated fatty acids were 36.52 ± 13.90%, and polyunsaturated fatty acids were 15.70 ± 7.10%. Polyunsaturated fatty acid sub-class n-6 was 15.23 ± 8.23% and n-3 was 0.46 ± 0.18%. Oleic acid, palmitic acid, and linoleic acid were the most abundant fatty acids. The n-6/n-3 ratio was 32.83:1. EPA and DHA fatty acids were not detected. As gestational age and birth weight increase, C20:2n6 content increases. The growth velocity increases with the decrement in C16 and increment in C20:2n6. The lipid profile of preterm human milk was found to be low in some essential fatty acids, which may affect the quality of preterm infants\' nutrition.
摘要：
本研究旨在分析人乳中脂肪酸含量及其与早产儿生长速度的关系。从三家不同的医院收集了15名早产儿母亲的成熟牛奶样本，然后是脂质提取，脂肪酸甲基化，最后进行气相色谱分析以确定脂肪酸组成。平均总脂质含量为3.61±1.57g/100mL，具有以下类别的脂肪酸：饱和脂肪酸43.54±11.16％，不饱和脂肪酸52.22±10.89%，其中单不饱和脂肪酸为36.52±13.90%，多不饱和脂肪酸为15.70±7.10%。多不饱和脂肪酸亚类n-6为15.23±8.23%,n-3为0.46±0.18%。油酸,棕榈酸,亚油酸是最丰富的脂肪酸。n-6/n-3比为32.83:1。未检测到EPA和DHA脂肪酸。随着胎龄和出生体重的增加，C20：2n6含量增加。生长速度随着C16的减小和C20：2n6的增加而增加。发现早产人乳的脂质分布在某些必需脂肪酸中很低，这可能会影响早产儿的营养质量。
