PDF(Pubmed)
Abstract：
Pancreatic cancer (PC) has an unfavorable prognosis with few effective therapeutic options. This has led researchers to investigate the possible links between microbiota and PC. A disrupted gut microbiome can lead to chronic inflammation, which is involved in the pathogenesis of PC. In addition, some bacterial strains can produce carcinogens that promote the growth of cancer cells. Research has also focused on pancreatic and oral microbiota. Changes in these microbiota can contribute to the development and progression of PC. Furthermore, patients with periodontal disease have an increased risk of developing PC. The potential use of microbiota as a prognostic marker or to predict patients\' responses to chemotherapy or immunotherapy is also being explored. Overall, the role of microbiota-including the gut, pancreatic, and oral microbiota-in PC is an active research area. Understanding these associations could lead to new diagnostic and therapeutic targets for this deadly disease.
摘要：
胰腺癌（PC）预后不良，几乎没有有效的治疗选择。这导致研究人员研究微生物群和PC之间的可能联系。肠道微生物群的破坏会导致慢性炎症，这与PC的发病机制有关。此外,一些细菌菌株可以产生促进癌细胞生长的致癌物质。研究还集中在胰腺和口腔微生物群。这些微生物群的变化可以促进PC的发展和进展。此外，牙周病患者患PC的风险增加.微生物群作为预后标志物或预测患者对化疗或免疫治疗反应的潜在用途也在探索中。总的来说,包括肠道在内的微生物群的作用，胰腺,PC中的口腔微生物群是一个活跃的研究领域。了解这些关联可能会导致这种致命疾病的新诊断和治疗目标。
