PDF(Pubmed)
Abstract：
Adipose tissue is composed of a collection of cells with valuable structural and regenerative function. Taken as an autologous graft, these cells can be used to address soft tissue defects and irregularities, while also providing a reparative effect on the surrounding tissues. Adipose-derived stem or stromal cells are primarily responsible for this regenerative effect through direct differentiation into native cells and via secretion of numerous growth factors and cytokines that stimulate angiogenesis and disrupt pro-inflammatory pathways. Separating adipose tissue into its component parts, i.e., cells, scaffolds and proteins, has provided new regenerative therapies for skin and soft tissue pathology, including that resulting from radiation. Recent studies in both animal models and clinical trials have demonstrated the ability of autologous fat grafting to reverse radiation induced skin fibrosis. An improved understanding of the complex pathologic mechanism of RIF has allowed researchers to harness the specific function of the ASCs to engineer enriched fat graft constructs to improve the therapeutic effect of AFG.
摘要：
脂肪组织由具有有价值的结构和再生功能的细胞集合组成。作为自体移植物，这些细胞可用于解决软组织缺陷和不规则，同时还对周围组织提供修复作用。脂肪来源的干细胞或基质细胞通过直接分化成天然细胞和通过分泌刺激血管生成和破坏促炎途径的多种生长因子和细胞因子而主要负责这种再生作用。将脂肪组织分成组成部分，即，细胞,支架和蛋白质，为皮肤和软组织病理学提供了新的再生疗法，包括辐射造成的。最近在动物模型和临床试验中的研究已经证明了自体脂肪移植逆转辐射诱导的皮肤纤维化的能力。对RIF复杂病理机制的更好理解使研究人员能够利用ASCs的特定功能来设计富集的脂肪移植物构建体以改善AFG的治疗效果。
