PDF(Pubmed)
Abstract：
Antimicrobial resistance (AMR) has become a major healthcare concern having a rising incidence, especially in pediatric patients who are more susceptible to infections. The aim of our study was to analyze the bacterial species isolated from patients admitted to our tertiary hospital and their AMR profiles. We conducted a retrospective observational study by examining the bacterial cultures collected from pediatric patients admitted to our hospital over a period of one year. We identified the most common bacterial species from 1445 clinical isolates and their AMR patterns using standard microbiological techniques. Our analysis revealed that the most frequently isolated bacterial species were Escherichia coli (23.73%), Staphylococcus aureus (15.64%), Klebsiella species (12.04%), and Pseudomonas species (9.96%). Additionally, these species exhibited varying levels of resistance to commonly used antibiotics. Notably, we observed high rates of resistance among Gram-negative bacteria, including extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. Among Gram-positive bacteria, we observed a high level of methicillin-resistant Staphylococcus aureus. Our findings highlight the urgent need for effective antibiotic management programs and infection control measures to address the rising incidence of AMR in pediatric hospitals. Further research is needed to identify the mechanisms of resistance in these bacterial species and to develop new strategies for preventing and treating infections caused by antibiotic-resistant bacteria in pediatric patients.
摘要：
抗菌素耐药性(AMR)已成为一个主要的医疗保健问题，发病率不断上升。尤其是在更容易感染的儿科患者中。我们研究的目的是分析从三级医院住院的患者中分离出的细菌种类及其AMR谱。我们通过检查从住院一年的儿科患者收集的细菌培养物进行了回顾性观察研究。我们使用标准微生物学技术从1445个临床分离株中鉴定了最常见的细菌种类及其AMR模式。我们的分析表明，最常见的细菌种类是大肠杆菌（23.73％），金黄色葡萄球菌（15.64%），克雷伯菌属(12.04%),和假单胞菌(9.96%)。此外,这些物种对常用抗生素表现出不同程度的抗性。值得注意的是,我们观察到革兰氏阴性菌耐药率高，包括产超广谱β-内酰胺酶的大肠杆菌和克雷伯菌属。在革兰氏阳性菌中，我们观察到高水平的耐甲氧西林金黄色葡萄球菌。我们的发现强调了迫切需要有效的抗生素管理计划和感染控制措施，以解决儿科医院AMR发病率上升的问题。需要进一步的研究来确定这些细菌的耐药机制，并开发预防和治疗儿科患者抗生素耐药细菌引起的感染的新策略。
