Abstract：
Postoperative nausea and vomiting (PONV) is a common and unpleasant complication of general anesthesia. There are well-known risk factors that predispose a patient to develop PONV. While studies exist that explore PONV incidence in gravid and non-gravid women separately, limited studies exist to compare the two cohorts to identify if pregnancy is associated with increased risk for PONV or differences in PONV prophylaxis and treatment.
This is a retrospective case-control cohort study, with 1:2 matching based on age, year of surgery, and surgical procedure. Electronic medical records were abstracted for demographic information, predisposing risk factors, prophylactic antiemetics, PONV documentation, rescue antiemetics, PACU stay, and length of hospitalization. Analyses of risk factors for PONV were performed using logistic and multinomial logistic regression analyses.
237 gravid women who underwent non-obstetric procedures with general anesthesia were identified and matched with 474 non-gravid women. PONV complicated the course of 51 (21.5%) gravid and 72 (15.2%) non-gravid women. The number of prophylactic antiemetics was fewer among gravid (median 2 [1, 2]) than non-gravid (3 [2, 3]) women (P < 0.001). No association was found between gravid status and risk for PONV (adjusted odds ratio 1.35 [95%CI 0.84, 2.17], P = 0.222). Gravid women had longer hospital lengths of stay (P < 0.001), despite having shorter surgical duration (P = 0.015).
The risk for PONV is similar between gravid and similarly aged women. However, anesthesiologists administer fewer prophylactic antiemetics to gravid women during non-obstetric surgery.
This is a retrospective case-control cohort study, with 1:2 matching based on age, year of surgery, and surgical procedure. Electronic medical records were abstracted for demographic information, predisposing risk factors, prophylactic antiemetics, PONV documentation, rescue antiemetics, PACU stay, and length of hospitalization. Analyses of risk factors for PONV were performed using logistic and multinomial logistic regression analyses.
237 gravid women who underwent non-obstetric procedures with general anesthesia were identified and matched with 474 non-gravid women. PONV complicated the course of 51 (21.5%) gravid and 72 (15.2%) non-gravid women. The number of prophylactic antiemetics was fewer among gravid (median 2 [1, 2]) than non-gravid (3 [2, 3]) women (P < 0.001). No association was found between gravid status and risk for PONV (adjusted odds ratio 1.35 [95%CI 0.84, 2.17], P = 0.222). Gravid women had longer hospital lengths of stay (P < 0.001), despite having shorter surgical duration (P = 0.015).
The risk for PONV is similar between gravid and similarly aged women. However, anesthesiologists administer fewer prophylactic antiemetics to gravid women during non-obstetric surgery.
摘要：
背景：术后恶心和呕吐（PONV）是全身麻醉的常见且令人不快的并发症。有众所周知的风险因素使患者容易发生PONV。虽然有研究分别探讨妊娠和非妊娠妇女的PONV发生率，目前有有限的研究来比较这两个队列,以确定妊娠是否与PONV风险增加或PONV预防和治疗的差异相关.
方法：这是一项回顾性病例对照队列研究，根据年龄进行1:2匹配，手术年份,和外科手术。电子病历被抽象为人口统计信息，易感风险因素，预防性止吐药,PONV文档,拯救止吐药，PACU撑开,和住院时间。使用logistic和多项logistic回归分析进行PONV的危险因素分析。
结果：237名接受了全身麻醉的非产科手术的妊娠妇女被确定为474名非妊娠妇女。PONV使51例（21.5％）妊娠妇女和72例（15.2％）非妊娠妇女的病程复杂化。孕妇（中位数2[1,2]）预防性止吐药的数量少于非孕妇（3[2,3]）（P<0.001）。妊娠状态与PONV风险之间未发现关联（调整后的比值比1.35[95CI0.84，2.17]，P=0.222）。妊娠妇女住院时间较长（P<0.001），尽管手术时间较短（P=0.015）。
结论：妊娠和类似年龄的女性发生PONV的风险相似。然而,在非产科手术期间,麻醉医师对妊娠妇女使用较少的预防性止吐药.
方法：这是一项回顾性病例对照队列研究，根据年龄进行1:2匹配，手术年份,和外科手术。电子病历被抽象为人口统计信息，易感风险因素，预防性止吐药,PONV文档,拯救止吐药，PACU撑开,和住院时间。使用logistic和多项logistic回归分析进行PONV的危险因素分析。
结果：237名接受了全身麻醉的非产科手术的妊娠妇女被确定为474名非妊娠妇女。PONV使51例（21.5％）妊娠妇女和72例（15.2％）非妊娠妇女的病程复杂化。孕妇（中位数2[1,2]）预防性止吐药的数量少于非孕妇（3[2,3]）（P<0.001）。妊娠状态与PONV风险之间未发现关联（调整后的比值比1.35[95CI0.84，2.17]，P=0.222）。妊娠妇女住院时间较长（P<0.001），尽管手术时间较短（P=0.015）。
结论：妊娠和类似年龄的女性发生PONV的风险相似。然而,在非产科手术期间,麻醉医师对妊娠妇女使用较少的预防性止吐药.
