PDF(Pubmed)
Abstract：
The effects of the consumption of an extract of the brown seaweed Ascophyllum nodosum (BSW) on postprandial glucose and insulin responses to white bread were investigated in an acute, randomized, double-blind, three-arm, crossover, controlled trial in healthy, normoglycemic subjects. Sixteen subjects were administered either control white bread (50 g total digestible carbohydrates) or white bread with 500 mg or 1000 mg of BSW extract. Biochemical parameters were measured in venous blood over 3 h. Significant inter-individual variation in the glycaemic response to white bread was observed. Analysis of the responses of all subjects to either 500 mg or 1000 mg of BSW extract versus control revealed no significant effects of treatments. The variation in response to the control was used to classify individuals into glycaemic responders and non-responders. In the sub-cohort of 10 subjects with peak glucose levels after white bread above 1 mmol/L, we observed a significant decrease in maximum levels of plasma glucose after the intervention meal with 1000 mg of extract compared with the control. No adverse effects were reported. Further work is warranted to define all factors that determine \"responders\" to the effects of brown seaweed extracts and identify the cohort that would benefit the most from their consumption.
摘要：
研究了食用褐藻夜蛾提取物（BSW）对餐后葡萄糖和胰岛素对白面包的反应的影响。随机化，双盲,三臂,交叉，健康的对照试验，血糖正常的受试者。给16名受试者施用对照白面包(50g总可消化碳水化合物)或含500mg或1000mgBSW提取物的白面包。在3小时内测量静脉血中的生化参数。观察到对白面包的血糖反应的显着个体间变化。对所有受试者对500mg或1000mg的BSW提取物与对照的反应的分析显示,治疗没有显著作用。响应于对照的变化用于将个体分类为血糖应答者和非应答者。在10名受试者的亚组中，白面包后的血糖峰值水平高于1mmol/L，与对照组相比,我们观察到1000mg提取物干预餐后的最大血糖水平显著下降.无不良反应报告。需要进一步的工作来定义确定“响应者”对褐藻提取物的影响的所有因素，并确定将从其消费中受益最多的队列。
