Abstract：
UNASSIGNED: Campylobacter jejuni is the leading cause of zoonotic gastroenteritis. The other emerging group of Campylobacters spp. are part of human oral commensal, represented by C. concisus (CC), which has been recently linked to non-oral conditions. Although long-term gastrointestinal (GI) complications from these two groups of Campylobacters have been previously reviewed individually, overall impact of Campylobacter infection on GI carcinogenesis and their inflammatory precursor lesions has not been assessed collectively.
UNASSIGNED: To evaluate the available evidence concerning the association between Campylobacter infection/colonization and inflammatory bowel disease (IBD), reflux esophagitis/metaplasia colorectal cancer (CRC) and esophageal cancer (EC).
UNASSIGNED: We performed a comprehensive literature search of PubMed for relevant original publications and systematic reviews/meta-analyses of epidemiological and clinical studies. In addition, we gathered additional information concerning microbiological data, animal models and mechanistic data from in vitro studies.
UNASSIGNED: Both retrospective and prospective studies on IBD showed relatively consistent increased risk associated with Campylobacter infection. Despite lack of supporting prospective studies, retrospective studies based on tissue/fecal microbiome revealed consistent enrichment of Campylobacter in CRC samples. Studies on EC precursor lesions (esophagitis and metaplasia) were generally supportive for the association with Campylobacter, while inconsistent observations on EC. Studies on both IBD and EC precursors suggested the predominant role of CC, but studies on CRC were not informative of species.
UNASSIGNED: There is sufficient evidence calling for concerted effort in unveiling direct and indirect connection of this organism to colorectal and esophageal cancer in humans.
UNASSIGNED: To evaluate the available evidence concerning the association between Campylobacter infection/colonization and inflammatory bowel disease (IBD), reflux esophagitis/metaplasia colorectal cancer (CRC) and esophageal cancer (EC).
UNASSIGNED: We performed a comprehensive literature search of PubMed for relevant original publications and systematic reviews/meta-analyses of epidemiological and clinical studies. In addition, we gathered additional information concerning microbiological data, animal models and mechanistic data from in vitro studies.
UNASSIGNED: Both retrospective and prospective studies on IBD showed relatively consistent increased risk associated with Campylobacter infection. Despite lack of supporting prospective studies, retrospective studies based on tissue/fecal microbiome revealed consistent enrichment of Campylobacter in CRC samples. Studies on EC precursor lesions (esophagitis and metaplasia) were generally supportive for the association with Campylobacter, while inconsistent observations on EC. Studies on both IBD and EC precursors suggested the predominant role of CC, but studies on CRC were not informative of species.
UNASSIGNED: There is sufficient evidence calling for concerted effort in unveiling direct and indirect connection of this organism to colorectal and esophageal cancer in humans.
摘要：
■空肠弯曲菌是人畜共患性胃肠炎的主要原因。其他新兴群体的弯曲菌属。是人类口腔共生的一部分，由C.concisus(CC)代表，最近与非口腔疾病有关。尽管这两组弯曲层的长期胃肠道（GI）并发症以前已经单独进行了审查，弯曲杆菌感染对胃肠道癌变及其炎性前体性病变的总体影响尚未统一评估.
■为了评估有关弯曲杆菌感染/定植与炎症性肠病（IBD）之间关联的现有证据，反流性食管炎/上皮化生结直肠癌（CRC）和食管癌（EC）。
■我们对PubMed进行了全面的文献检索，以获取相关的原始出版物以及流行病学和临床研究的系统评价/荟萃分析。此外,我们收集了有关微生物数据的更多信息，动物模型和体外研究的机理数据。
■关于IBD的回顾性和前瞻性研究均显示与弯曲杆菌感染相关的风险相对一致地增加。尽管缺乏支持前瞻性研究，基于组织/粪便微生物组的回顾性研究揭示了CRC样本中弯曲杆菌的持续富集.关于EC前体病变（食管炎和上皮化生）的研究通常支持与弯曲杆菌的关联，而对欧共体的观察不一致。对IBD和EC前体的研究表明，CC的主要作用，但是关于CRC的研究没有提供物种信息。
■有足够的证据要求共同努力揭示这种生物与人类结直肠癌和食管癌的直接和间接联系。
■为了评估有关弯曲杆菌感染/定植与炎症性肠病（IBD）之间关联的现有证据，反流性食管炎/上皮化生结直肠癌（CRC）和食管癌（EC）。
■我们对PubMed进行了全面的文献检索，以获取相关的原始出版物以及流行病学和临床研究的系统评价/荟萃分析。此外,我们收集了有关微生物数据的更多信息，动物模型和体外研究的机理数据。
■关于IBD的回顾性和前瞻性研究均显示与弯曲杆菌感染相关的风险相对一致地增加。尽管缺乏支持前瞻性研究，基于组织/粪便微生物组的回顾性研究揭示了CRC样本中弯曲杆菌的持续富集.关于EC前体病变（食管炎和上皮化生）的研究通常支持与弯曲杆菌的关联，而对欧共体的观察不一致。对IBD和EC前体的研究表明，CC的主要作用，但是关于CRC的研究没有提供物种信息。
■有足够的证据要求共同努力揭示这种生物与人类结直肠癌和食管癌的直接和间接联系。
