Abstract：
OBJECTIVE: The number of lymph nodes is used to determine the prognosis in patients with gastric cancer undergoing D2 lymph node dissection. However, a group of extraperigastric lymph nodes, including lymph node 8a, are also considered to be effective in prognosis. In our clinical experience, in most patients during D2 lymph node dissection, the lymph nodes are removed en-bloc with the specimen and are not marked separately. The aim was to analyze the importance and prognostic impact of 8a lymph node metastasis in patients with gastric cancer.
METHODS: Patients who underwent gastrectomy and D2 lymph node dissection for gastric cancer between 2015 and 2022 were included in the study. Patients were divided into two groups based on metastasis to the 8a lymph node: metastatic and nonmetastatic. The effect of clinicopathologic features and the prevalence of lymph node metastasis on the prognosis of the two groups were analyzed.
RESULTS: The present study included 78 patients. The mean number of dissected lymph nodes was 27 (IQR, 15-62). There were 22 (28.2%) patients in the 8a lymph node metastatic group. Patients with 8a lymph node metastatic disease had shorter overall survival and shorter disease-free survival. Those with metastatic 8a lymph nodes among pathologic N2/3 patients had shorter overall and disease-free survival rates (p < 0.05).
CONCLUSIONS: In conclusion, we believe that anterior common hepatic artery (8a) LN metastasis is a key factor that negatively affects both disease-free and overall survival in patients with locally advanced gastric cancer.
METHODS: Patients who underwent gastrectomy and D2 lymph node dissection for gastric cancer between 2015 and 2022 were included in the study. Patients were divided into two groups based on metastasis to the 8a lymph node: metastatic and nonmetastatic. The effect of clinicopathologic features and the prevalence of lymph node metastasis on the prognosis of the two groups were analyzed.
RESULTS: The present study included 78 patients. The mean number of dissected lymph nodes was 27 (IQR, 15-62). There were 22 (28.2%) patients in the 8a lymph node metastatic group. Patients with 8a lymph node metastatic disease had shorter overall survival and shorter disease-free survival. Those with metastatic 8a lymph nodes among pathologic N2/3 patients had shorter overall and disease-free survival rates (p < 0.05).
CONCLUSIONS: In conclusion, we believe that anterior common hepatic artery (8a) LN metastasis is a key factor that negatively affects both disease-free and overall survival in patients with locally advanced gastric cancer.
摘要：
目的：淋巴结数目用于判断胃癌D2淋巴结清扫术患者的预后。然而,一组胃外淋巴结,包括淋巴结8a，也被认为是有效的预后。根据我们的临床经验，大多数患者在D2淋巴结清扫术中，淋巴结与标本一起切除，未单独标记。目的分析8a淋巴结转移在胃癌患者中的重要性及对预后的影响。
方法：在2015年至2022年期间接受胃切除术和D2淋巴结清扫术的胃癌患者被纳入研究。根据8a淋巴结的转移将患者分为两组：转移性和非转移性。分析两组患者临床病理特征及淋巴结转移情况对预后的影响。
结果：本研究包括78例患者。平均解剖淋巴结数为27(IQR，15-62).8a淋巴结转移组22例(28.2%)。患有8a淋巴结转移疾病的患者总生存期较短，无病生存期较短。病理N2/3患者中转移8a淋巴结的患者总体生存率和无病生存率较短（p<0.05）。
结论：结论：我们认为,肝共同前动脉(8a)LN转移是对局部进展期胃癌患者的无病生存率和总生存率均有负面影响的关键因素.
方法：在2015年至2022年期间接受胃切除术和D2淋巴结清扫术的胃癌患者被纳入研究。根据8a淋巴结的转移将患者分为两组：转移性和非转移性。分析两组患者临床病理特征及淋巴结转移情况对预后的影响。
结果：本研究包括78例患者。平均解剖淋巴结数为27(IQR，15-62).8a淋巴结转移组22例(28.2%)。患有8a淋巴结转移疾病的患者总生存期较短，无病生存期较短。病理N2/3患者中转移8a淋巴结的患者总体生存率和无病生存率较短（p<0.05）。
结论：结论：我们认为,肝共同前动脉(8a)LN转移是对局部进展期胃癌患者的无病生存率和总生存率均有负面影响的关键因素.
