PDF(Pubmed)
Abstract：
The cytokine storm is a complication related to SARS-CoV-2 infection worldwide. This study aimed to address the level of three cytokines which were interleukin-1-beta (IL-1β), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α), with different blood parameters to the formation of cytokine storm or any complication among COVID-19 patients.
UNASSIGNED: A total of 104 serum samples were included for this purpose, and they were divided into three categories the healthy control group (n=30), mild COVID-19 patients (n=23), and severe cases of COVID-19 patients (n=51). The cytokine concentration was measured by enzyme-linked immunosorbent assays (ELISA). Serum ferritin, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate were also evaluated and compared with the concentration of the proinflammatory cytokines.
UNASSIGNED: The data analysis showed a significant relationship between the serum IL-6 level with serum ferritin and CRP and the progression to the severity of SARS-CoV-2 infection. The IL-6 level was increased in mild COVID-19 patients and was significantly elevated in severe COVID-19 patients. Patients in the severe group had significantly higher serum ferritin, CRP, and erythrocyte sedimentation rate levels than those in the mild and healthy groups. The IL-1β and TNF-α were not significantly different in the groups compared with the healthy control group.
UNASSIGNED: This study revealed that the proinflammatory cytokines and biochemical laboratory tests are promising biomarkers for detecting the severity of COVID-19 cases.
UNASSIGNED: A total of 104 serum samples were included for this purpose, and they were divided into three categories the healthy control group (n=30), mild COVID-19 patients (n=23), and severe cases of COVID-19 patients (n=51). The cytokine concentration was measured by enzyme-linked immunosorbent assays (ELISA). Serum ferritin, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate were also evaluated and compared with the concentration of the proinflammatory cytokines.
UNASSIGNED: The data analysis showed a significant relationship between the serum IL-6 level with serum ferritin and CRP and the progression to the severity of SARS-CoV-2 infection. The IL-6 level was increased in mild COVID-19 patients and was significantly elevated in severe COVID-19 patients. Patients in the severe group had significantly higher serum ferritin, CRP, and erythrocyte sedimentation rate levels than those in the mild and healthy groups. The IL-1β and TNF-α were not significantly different in the groups compared with the healthy control group.
UNASSIGNED: This study revealed that the proinflammatory cytokines and biochemical laboratory tests are promising biomarkers for detecting the severity of COVID-19 cases.
摘要：
细胞因子风暴是全球范围内与SARS-CoV-2感染有关的并发症。这项研究旨在解决三种细胞因子的水平，白细胞介素-1-β（IL-1β），白细胞介素-6（IL-6），和肿瘤坏死因子-α（TNF-α），COVID-19患者中不同的血液参数导致细胞因子风暴或任何并发症的形成。
■为此目的共纳入104份血清样本，他们分为三类健康对照组（n=30），轻度COVID-19患者（n=23），和COVID-19患者的重症病例（n=51）。通过酶联免疫吸附测定(ELISA)测量细胞因子浓度。血清铁蛋白,C反应蛋白(CRP)水平,还评估了红细胞沉降率，并将其与促炎细胞因子的浓度进行了比较。
■数据分析显示血清IL-6水平与血清铁蛋白和CRP与SARS-CoV-2感染严重程度的进展之间存在显着关系。轻度COVID-19患者的IL-6水平升高，重度COVID-19患者的IL-6水平显着升高。重症组患者血清铁蛋白明显增高,CRP,和红细胞沉降率水平高于轻度和健康组。各组IL-1β、TNF-α与健康对照组比较差异无统计学意义。
■这项研究表明，促炎细胞因子和生化实验室测试是检测COVID-19病例严重程度的有希望的生物标志物。
■为此目的共纳入104份血清样本，他们分为三类健康对照组（n=30），轻度COVID-19患者（n=23），和COVID-19患者的重症病例（n=51）。通过酶联免疫吸附测定(ELISA)测量细胞因子浓度。血清铁蛋白,C反应蛋白(CRP)水平,还评估了红细胞沉降率，并将其与促炎细胞因子的浓度进行了比较。
■数据分析显示血清IL-6水平与血清铁蛋白和CRP与SARS-CoV-2感染严重程度的进展之间存在显着关系。轻度COVID-19患者的IL-6水平升高，重度COVID-19患者的IL-6水平显着升高。重症组患者血清铁蛋白明显增高,CRP,和红细胞沉降率水平高于轻度和健康组。各组IL-1β、TNF-α与健康对照组比较差异无统计学意义。
■这项研究表明，促炎细胞因子和生化实验室测试是检测COVID-19病例严重程度的有希望的生物标志物。
