UNASSIGNED: One hundred and nine consecutive patients affected by LA-SCCHN and treated with at least a cumulative dosage of 200 mg/m2 of cisplatin concomitant with radiotherapy were enrolled in this prospective observational study.
UNASSIGNED: AKI was reported in 12.8% of patients, 50% of whom were stage 1 (KDIGO criteria), while 25.7% of the cohort developed AKD. Patients with baseline estimated Glomerular Filtration Rate (eGFR) < 90 ml/min showed a higher incidence of AKD (36.2% vs 17.7%). Hypertension, baseline eGFR, and therapy with Renin-angiotensin-aldosterone system inhibitors proved to be significant factors associated with both AKI and AKD.
UNASSIGNED: AKI and AKD are not rare complications of high-dose cisplatin, but an appropriate prevention strategy and accurate monitoring of patients during treatment could lead to a reduction of the burden of these conditions.
■这项前瞻性观察性研究纳入了109名连续的LA-SCCHN患者,并同时接受至少200mg/m2顺铂的累积剂量和放疗。
■在12.8%的患者中报告了AKI,其中50%是第一阶段(KDIGO标准),而25.7%的队列发生AKD。基线估计肾小球滤过率(eGFR)<90ml/min的患者显示出更高的AKD发生率(36.2%vs17.7%)。高血压,基线eGFR,肾素-血管紧张素-醛固酮系统抑制剂治疗被证明是与AKI和AKD相关的重要因素。
■AKI和AKD是大剂量顺铂的罕见并发症,但适当的预防策略和治疗期间对患者的准确监测可以减轻这些疾病的负担.