PDF(Pubmed)
Abstract：
Cyclopropene derivatives have been used as extremely reactive units in organic chemistry owing to their high ring-strain energy. They have become popular reagents both for bioorthogonal chemistry and for chemical biology because of their small size and ability to be genetically encoded. In this context, we conducted an exploratory study to identify the biologically active cyclopropenes that affect normal plant growth. We synthesized several cycloprop-2-ene-1-carboxylic acid derivatives and evaluated their effects on the early growth stage of Arabidopsis thaliana. Eventually, we identified the chemicals that affect apical hook development in Arabidopsis thaliana. Their mode of action is different from those of ethylene receptor inhibition and gibberellin biosynthesis inhibition. We expect that some of the chemicals reported here can be new tools in chemical biology to determine useful molecular targets for herbicides or plant growth regulators.
摘要：
环丙烯衍生物由于其高的环应变能而在有机化学中被用作极具反应性的单元。由于它们的小尺寸和被基因编码的能力，它们已经成为生物正交化学和化学生物学的流行试剂。在这种情况下，我们进行了一项探索性研究，以确定影响植物正常生长的生物活性环丙烯。我们合成了几种环丙-2-烯-1-羧酸衍生物，并评估了它们对拟南芥早期生长阶段的影响。最终,我们确定了影响拟南芥根尖钩发育的化学物质。它们的作用方式不同于乙烯受体抑制和赤霉素生物合成抑制。我们希望这里报道的一些化学物质可以成为化学生物学中的新工具，以确定除草剂或植物生长调节剂的有用分子靶标。
