PDF(Pubmed)
Abstract：
BACKGROUND: Eosinophilic granuloma (EG) belongs to the family of Langerhans cell histiocytosis (LCH) and is considered to be a benign disease typically found in children younger than 15 years of age. Here, the authors describe an EG of unusual localization and clinical presentation.
METHODS: The authors report a 9-year-old girl with an EG presenting as an osteolytic lesion of the clivus. After transsphenoidal resection and histological confirmation, adjuvant chemotherapy was initiated. Presenting signs and symptoms were weight loss, episodic grimacing, and moderate ballism-like movements. After a follow-up-period of 32 months, the patient presented with a total resolution of initial symptoms and no further tumor growth.
CONCLUSIONS: Although these lesions are rare, one should consider EG as a differential diagnosis when confronted with osteolytic lesions of the clivus.
METHODS: The authors report a 9-year-old girl with an EG presenting as an osteolytic lesion of the clivus. After transsphenoidal resection and histological confirmation, adjuvant chemotherapy was initiated. Presenting signs and symptoms were weight loss, episodic grimacing, and moderate ballism-like movements. After a follow-up-period of 32 months, the patient presented with a total resolution of initial symptoms and no further tumor growth.
CONCLUSIONS: Although these lesions are rare, one should consider EG as a differential diagnosis when confronted with osteolytic lesions of the clivus.
摘要：
背景嗜酸性肉芽肿（EG）属于朗格汉斯细胞组织细胞增生症（LCH）家族，被认为是一种良性疾病，通常见于15岁以下儿童。这里,作者描述了EG的异常定位和临床表现。
方法：作者报告了一个9岁的女孩，其EG表现为斜坡的溶骨性病变。经蝶窦切除和组织学确认后，开始辅助化疗。表现出的体征和症状是体重减轻，偶发的鬼脸,和温和的类似弹道的运动。经过32个月的随访，患者的初始症状完全缓解,肿瘤无进一步生长.
结论：尽管这些病变很少见，当遇到斜坡的溶骨性病变时，应将EG视为鉴别诊断。
方法：作者报告了一个9岁的女孩，其EG表现为斜坡的溶骨性病变。经蝶窦切除和组织学确认后，开始辅助化疗。表现出的体征和症状是体重减轻，偶发的鬼脸,和温和的类似弹道的运动。经过32个月的随访，患者的初始症状完全缓解,肿瘤无进一步生长.
结论：尽管这些病变很少见，当遇到斜坡的溶骨性病变时，应将EG视为鉴别诊断。
