Abstract：
OBJECTIVE: To report the association of tilted disc (TD) with fovea plana.
METHODS: Monocentric retrospective study of consecutive eyes diagnosed with fovea plana, assessed by spectral-domain optical coherence tomography. Analysis of the medical charts and imaging findings of patients to collect demographics, the visual acuity, and the clinical context. The presence of associated conditions was checked by two independent readers in order to classify fovea plana as isolated or part of other conditions.
RESULTS: Twenty-one patients, 9 men and 12 women, aged 12 to 91 years, were included. Fovea plana was isolated and asymptomatic in 10 (47.6%) patients. In 6 (28.5%) patients, fovea plana was associated with ocular albinism and/or nystagmus. In 6 (28.5%) patients, fovea plana was associated with an obliquity of the optic disc typical of TD, isolated (5 cases), or associated with nystagmus (1 case).
CONCLUSIONS: An association between TD and fovea plana had been reported only once in the literature and had been considered likely coincidental. However, this association could be more common than initially reported and suggests a common pathological process in eye development during embryogenesis.
METHODS: Monocentric retrospective study of consecutive eyes diagnosed with fovea plana, assessed by spectral-domain optical coherence tomography. Analysis of the medical charts and imaging findings of patients to collect demographics, the visual acuity, and the clinical context. The presence of associated conditions was checked by two independent readers in order to classify fovea plana as isolated or part of other conditions.
RESULTS: Twenty-one patients, 9 men and 12 women, aged 12 to 91 years, were included. Fovea plana was isolated and asymptomatic in 10 (47.6%) patients. In 6 (28.5%) patients, fovea plana was associated with ocular albinism and/or nystagmus. In 6 (28.5%) patients, fovea plana was associated with an obliquity of the optic disc typical of TD, isolated (5 cases), or associated with nystagmus (1 case).
CONCLUSIONS: An association between TD and fovea plana had been reported only once in the literature and had been considered likely coincidental. However, this association could be more common than initially reported and suggests a common pathological process in eye development during embryogenesis.
摘要：
目的：报告倾斜椎间盘（TD）与中央凹平面的关系。
方法：连续诊断为中央凹的眼睛的单中心回顾性研究，通过谱域光学相干断层扫描进行评估。分析患者的医疗图表和影像学发现，以收集人口统计数据，视敏度，和临床背景。由两个独立的读取器检查相关病症的存在,以便将中央凹平面分类为孤立的或其他病症的一部分。
结果：21名患者，9男12女,12至91岁，包括在内。10例（47.6％）患者孤立且无症状。在6名（28.5％）患者中，中央凹与眼白化病和/或眼球震颤有关。在6名（28.5％）患者中，中央凹平面与典型的TD视盘倾斜有关，孤立（5例），或伴有眼球震颤（1例）。
结论：文献中仅报道了一次TD与中央凹平面之间的关联，并认为可能是巧合。然而,这种关联可能比最初报道的更为常见,提示胚胎发育过程中眼睛发育的共同病理过程.
方法：连续诊断为中央凹的眼睛的单中心回顾性研究，通过谱域光学相干断层扫描进行评估。分析患者的医疗图表和影像学发现，以收集人口统计数据，视敏度，和临床背景。由两个独立的读取器检查相关病症的存在,以便将中央凹平面分类为孤立的或其他病症的一部分。
结果：21名患者，9男12女,12至91岁，包括在内。10例（47.6％）患者孤立且无症状。在6名（28.5％）患者中，中央凹与眼白化病和/或眼球震颤有关。在6名（28.5％）患者中，中央凹平面与典型的TD视盘倾斜有关，孤立（5例），或伴有眼球震颤（1例）。
结论：文献中仅报道了一次TD与中央凹平面之间的关联，并认为可能是巧合。然而,这种关联可能比最初报道的更为常见,提示胚胎发育过程中眼睛发育的共同病理过程.
