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Abstract：
This review provides insight into the complex network of signaling pathways and mechanisms involved in stroke pathophysiology. It summarizes the historical progress of stroke-related signaling pathways, identifying potential interactions between them and emphasizing that stroke is a complex network disease. Of particular interest are the Hippo signaling pathway and ferroptosis signaling pathway, which remain understudied areas of research, and are therefore a focus of the review. The involvement of multiple signaling pathways, including Sonic Hedgehog (SHH), nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE), hypoxia-inducible factor-1α (HIF-1α), PI3K/AKT, JAK/STAT, and AMPK in pathophysiological mechanisms such as oxidative stress and apoptosis, highlights the complexity of stroke. The review also delves into the details of traditional Chinese medicine (TCM) therapies such as Rehmanniae and Astragalus, providing an analysis of the recent status of western medicine in the treatment of stroke and the advantages and disadvantages of TCM and western medicine in stroke treatment. The review proposes that since stroke is a network disease, TCM has the potential and advantages of a multi-target and multi-pathway mechanism of action in the treatment of stroke. Therefore, it is suggested that future research should explore more treasures of TCM and develop new therapies from the perspective of stroke as a network disease.
摘要：
这篇综述提供了有关中风病理生理学的信号通路和机制的复杂网络的见解。它总结了卒中相关信号通路的历史进展，识别它们之间的潜在相互作用，并强调中风是一种复杂的网络疾病。特别感兴趣的是Hippo信号通路和铁凋亡信号通路，这些仍然是研究不足的领域，因此是审查的重点。多个信号通路的参与，包括SonicHedgehog（SHH），核因子红系2相关因子2（Nrf2）/抗氧化反应元件（ARE），缺氧诱导因子-1α(HIF-1α),PI3K/AKT,JAK/STAT,和AMPK的病理生理机制，如氧化应激和细胞凋亡，突出了中风的复杂性。该评论还深入研究了中药（TCM）疗法的细节，例如地黄和黄芪，分析近年来西医治疗中风病的现状以及中西医治疗中风病的优缺点。该综述提出，由于中风是一种网络疾病，中医药在治疗中风方面具有多靶点、多途径作用机制的潜力和优势。因此,建议未来的研究应该从中风作为网络疾病的角度，探索更多的中医宝藏，开发新的疗法。
