PDF(Pubmed)
Abstract：
OBJECTIVE: To evaluate self-reported survey data provided by US oocyte donors on their experiences with ovarian hyperstimulation syndrome and possible correlations between OHSS severity and number of oocytes retrieved, trigger type, and prior OHSS history.
METHODS: An 85-question retrospective survey was administered online. Survey questions included demographic information, reasons for donating, immediate per-cycle experiences and outcomes, perceptions of informed consent, and perceived impact of donation on long-term health. Quantitative Data for this study was collected between February 2019 and September 2020 via QualtricsXM (January 2019), an online survey platform. Follow-up interviews were also conducted. Participants were recruited via fertility clinics, egg donation agencies, and online forum. The research was approved by the University of California, San Francisco Institutional Review Board (#14-14765).
RESULTS: Of 420 initiated US oocyte donor online surveys, 289 (68%) respondents provided detailed information on per cycle experiences with ovarian hyperstimulation syndrome, number of oocytes retrieved, and trigger type over a total of 801 cycles. On cycles where donors reported receiving GnRH agonist triggers (n = 337), they reported milder OHSS compared to cycles with hCG or dual triggers. Among donors undergoing multiple retrieval cycles, the severity of OHSS in second cycles was strongly associated with OHSS severity in first cycles.
CONCLUSIONS: Self-reported OHSS in oocyte donors is lower in GnRH antagonist stimulation protocols combined with GnRHa trigger and in cycles where donors reported fewer than 30 oocytes retrieved. Donors who reported severe OHSS on a prior cycle were significantly more likely to experience severe OHSS on a subsequent cycle.
METHODS: An 85-question retrospective survey was administered online. Survey questions included demographic information, reasons for donating, immediate per-cycle experiences and outcomes, perceptions of informed consent, and perceived impact of donation on long-term health. Quantitative Data for this study was collected between February 2019 and September 2020 via QualtricsXM (January 2019), an online survey platform. Follow-up interviews were also conducted. Participants were recruited via fertility clinics, egg donation agencies, and online forum. The research was approved by the University of California, San Francisco Institutional Review Board (#14-14765).
RESULTS: Of 420 initiated US oocyte donor online surveys, 289 (68%) respondents provided detailed information on per cycle experiences with ovarian hyperstimulation syndrome, number of oocytes retrieved, and trigger type over a total of 801 cycles. On cycles where donors reported receiving GnRH agonist triggers (n = 337), they reported milder OHSS compared to cycles with hCG or dual triggers. Among donors undergoing multiple retrieval cycles, the severity of OHSS in second cycles was strongly associated with OHSS severity in first cycles.
CONCLUSIONS: Self-reported OHSS in oocyte donors is lower in GnRH antagonist stimulation protocols combined with GnRHa trigger and in cycles where donors reported fewer than 30 oocytes retrieved. Donors who reported severe OHSS on a prior cycle were significantly more likely to experience severe OHSS on a subsequent cycle.
摘要：
目的：评估美国卵母细胞捐献者提供的自我报告的调查数据，以了解他们患有卵巢过度刺激综合征的经历以及OHSS严重程度与获得的卵母细胞数量之间可能的相关性，触发器类型,和先前的OHSS历史。
方法：一项由85个问题组成的回顾性调查在网上进行。调查问题包括人口统计信息，捐赠的原因,每个周期的即时体验和结果，知情同意的观念，以及捐赠对长期健康的影响。本研究的定量数据是在2019年2月至2020年9月期间通过QualtricsXM（2019年1月）收集的，在线调查平台。还进行了后续访谈。参与者是通过生育诊所招募的，卵子捐赠机构,和在线论坛。这项研究得到了加州大学的批准，旧金山机构审查委员会(#14-14765)。
结果：在420项美国卵母细胞供体在线调查中，289（68％）受访者提供了有关卵巢过度刺激综合征每个周期经历的详细信息，回收的卵母细胞数量，和触发器类型在总共801个周期。在供体报告接受GnRH激动剂触发剂的周期中（n=337），与使用hCG或双触发剂的周期相比,他们报告的OHSS较温和.在经历多个检索周期的捐赠者中，第二周期OHSS严重程度与第一周期OHSS严重程度密切相关.
结论：在结合GnRHa触发的GnRH拮抗剂刺激方案以及在供体报告回收的卵母细胞少于30个周期中，卵母细胞供体中自我报告的OHSS较低。在先前周期中报告严重OHSS的捐赠者在随后的周期中更有可能经历严重的OHSS。
方法：一项由85个问题组成的回顾性调查在网上进行。调查问题包括人口统计信息，捐赠的原因,每个周期的即时体验和结果，知情同意的观念，以及捐赠对长期健康的影响。本研究的定量数据是在2019年2月至2020年9月期间通过QualtricsXM（2019年1月）收集的，在线调查平台。还进行了后续访谈。参与者是通过生育诊所招募的，卵子捐赠机构,和在线论坛。这项研究得到了加州大学的批准，旧金山机构审查委员会(#14-14765)。
结果：在420项美国卵母细胞供体在线调查中，289（68％）受访者提供了有关卵巢过度刺激综合征每个周期经历的详细信息，回收的卵母细胞数量，和触发器类型在总共801个周期。在供体报告接受GnRH激动剂触发剂的周期中（n=337），与使用hCG或双触发剂的周期相比,他们报告的OHSS较温和.在经历多个检索周期的捐赠者中，第二周期OHSS严重程度与第一周期OHSS严重程度密切相关.
结论：在结合GnRHa触发的GnRH拮抗剂刺激方案以及在供体报告回收的卵母细胞少于30个周期中，卵母细胞供体中自我报告的OHSS较低。在先前周期中报告严重OHSS的捐赠者在随后的周期中更有可能经历严重的OHSS。
