PDF(Pubmed)
Abstract：
This study aims to determine the relationship between systemic inflammatory biomarkers and primary acquired nasolacrimal duct obstruction and to evaluate whether they can be used as indicators in determining the risk of recurrence after dacryocystorhinostomy. This retrospective, comparative case series was conducted with 57 primary acquired nasolacrimal duct obstruction patients and 58 age- and gender-matched controls. All subjects underwent a complete ophthalmologic examination and complete blood count measurements. The mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index were significantly higher in patients with primary acquired nasolacrimal duct obstruction (p = 0.005, p = 0.01, and p = 0.003, respectively). In recurrent patients, the neutrophil-to-lymphocyte ratio was significantly higher than in those who did not develop a recurrence (p = 0.029). The area under the curve was determined as 0.775 (p = 0.029) for the neutrophil-to-lymphocyte ratio in predicting recurrence. The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index levels were significantly higher in patients with primary acquired nasolacrimal duct obstruction compared to healthy controls. The neutrophil-to-lymphocyte ratio might be used as a simple and inexpensive indicator for predicting recurrence in patients with primary acquired nasolacrimal duct obstruction.
摘要：
本研究旨在确定系统性炎症生物标志物与原发性获得性鼻泪管阻塞之间的关系，并评估它们是否可以用作确定泪囊鼻腔造口术后复发风险的指标。这次回顾，对57例原发性获得性鼻泪管阻塞患者和58例年龄和性别匹配的对照者进行了比较病例系列.所有受试者都接受了完整的眼科检查和全血细胞计数测量。中性粒细胞与淋巴细胞的平均比率,血小板与淋巴细胞比率，原发性获得性鼻泪管阻塞患者的全身免疫-炎症指数显著升高(分别为p=0.005,p=0.01和p=0.003).在复发患者中，中性粒细胞/淋巴细胞比率显著高于未发生复发的患者(p=0.029).预测复发的中性粒细胞与淋巴细胞比率的曲线下面积为0.775（p=0.029）。中性粒细胞与淋巴细胞的比率,血小板与淋巴细胞比率，与健康对照组相比，原发性获得性鼻泪管阻塞患者的全身免疫炎症指数水平明显更高。中性粒细胞与淋巴细胞的比率可用作预测原发性获得性鼻泪管阻塞患者复发的简单且廉价的指标。
