PDF(Pubmed)
Abstract：
The role of vitamin D and calcium use in the development of breast cancer among women in the general population is not clear. Furthermore, whether vitamin D and calcium supplement use are associated with breast cancer in high-risk populations has not been evaluated. Thus, we evaluated the association between vitamin D and/or calcium supplement use and breast cancer among women with a pathogenic variant (mutation) in BRCA1 or BRCA2. BRCA mutation carriers enrolled in a longitudinal study were invited to complete a supplemental questionnaire on lifetime supplement use. Cases included women with a prevalent diagnosis of invasive breast cancer, and controls had no history of breast cancer. Vitamin D and calcium use were categorized as never/ever use, and as tertiles of supplement intake (total average daily supplement use). Unconditional logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (CIs) of breast cancer. This study included 134 breast cancer cases and 276 controls. Women who used vitamin D-containing supplements had 46% lower odds of having breast cancer compared to those who never used supplements (OR 0.54; 95% CI 0.31, 0.91; p = 0.02). Increasing vitamin D and calcium supplement intake was inversely associated with the odds of having breast cancer (p-trend = 0.04). Findings were suggestively stronger among BRCA1 mutation carriers; however, analyses were limited by small strata. These findings suggest a potential inverse association between vitamin D and calcium supplementation and BRCA breast cancer. Additional studies are warranted to confirm these findings and accurately inform clinical care guidelines.
摘要：
维生素D和钙的使用在一般人群中女性乳腺癌发展中的作用尚不清楚。此外，在高危人群中,维生素D和钙补充剂的使用是否与乳腺癌相关尚未被评估.因此，在BRCA1或BRCA2有致病变异(突变)的女性中,我们评估了维生素D和/或钙补充剂的使用与乳腺癌之间的关联.邀请参加纵向研究的BRCA突变携带者完成关于终生补充剂使用的补充问卷。病例包括普遍诊断为浸润性乳腺癌的女性，对照组无乳腺癌病史。维生素D和钙的使用被归类为从未/从未使用过，以及补充摄入量的三元率(每日平均补充使用量)。非条件Logistic回归用于估计乳腺癌的比值比（OR）和95％置信区间（CI）。这项研究包括134例乳腺癌病例和276例对照。与从未使用过维生素D补充剂的女性相比，使用含维生素D补充剂的女性患乳腺癌的几率降低了46%(OR0.54;95%CI0.31,0.91;p=0.02)。增加维生素D和钙补充剂的摄入量与患乳腺癌的几率呈负相关（p趋势=0.04）。结果表明，BRCA1突变携带者的研究结果更强；然而，分析受到小地层的限制。这些发现表明维生素D和钙补充剂与BRCA乳腺癌之间存在潜在的负相关。有必要进行其他研究以确认这些发现并准确告知临床护理指南。
