Abstract：
Previous studies reported human immunodeficiency virus (HIV) could enhance human papillomavirus (HPV)-induced cervical cancer. Therefore, the burden of cervical cancer associated with HIV across different regions and time periods need to be assessed. We aim to investigate the global burden of cervical cancer associated with HIV infection. Age standardized rates (ASRs) of cervical cancer disability-adjusted life-years (DALYs) in females (≥15 years old) were calculated by standardization, according the age-specific DALYs numbers extracted from GBD data set 2019. Population attributable fractions was calculated by combining the published risk ratio, with the HIV prevalence (≥15 years old) from Joint United Nations Programme on HIV and AIDS (UNAIDS), and transferred to estimate the HIV-associated cervical cancer burden. Expected annual percentage changes (EAPCs) was calculated to describe the temporal trend of ASR from 1990 to 2019. Pearson correlation analysis were conducted to assess the correlation between the ASR or EAPCs and the socio-demographic index. The worldwide DALYs ASR caused by HIV-associated cervical cancer rose from 3.78 (95% confidence interval [CI]: 2.19-5.56) in 1990 to 9.50 (95% CI: 5.66-13.79) in 2019 per 100k population. In 2019, the region with the greatest burden was Eastern and Southern Africa, with the highest DALYs of 273 900 (95% CI: 149 100-476 400) and ASR of 254.44 per 100k population (95% CI: 168.86-329.28). Notably, the Eastern Europe and Central Asia regions had the highest EAPC (14.07%) of HIV-associated DALYs ASR. Women in Eastern and Southern Africa experience the greatest burden of HIV-associated cervical cancer, while the Eastern Europe and Central Asia regions had witnessed the largest increase over the last 30 years. Prioritize the promotion of HPV vaccination and cervical cancer screening for women living with HIV were crucial in these regions.
摘要：
先前的研究报道人类免疫缺陷病毒（HIV）可以增强人乳头瘤病毒（HPV）诱导的宫颈癌。因此,需要评估不同地区和不同时间段与HIV相关的宫颈癌负担.我们的目的是调查与HIV感染相关的宫颈癌的全球负担。女性（≥15岁）宫颈癌残疾调整寿命年（DALYs）的年龄标准化率（ASRs）通过标准化计算，根据从GBD数据集2019中提取的特定年龄DALYs数字。人口归因分数是通过结合公布的风险比计算得出的，联合国艾滋病毒和艾滋病联合规划署(艾滋病规划署)的艾滋病毒流行率(≥15岁)，并转移到估计与艾滋病毒相关的宫颈癌负担。计算了预期的年度百分比变化（EAPC），以描述1990年至2019年ASR的时间趋势。进行Pearson相关分析以评估ASR或EAPC与社会人口统计学指数之间的相关性。由HIV相关宫颈癌引起的全球DALYsASR从1990年的3.78（95％置信区间[CI]：2.19-5.56）上升到2019年的9.50（95％CI：5.66-13.79）。2019年，负担最大的地区是东部和南部非洲，最高DALY为273900(95%CI:149100-476400)，ASR为254.44/100k人口(95%CI:168.86-329.28)。值得注意的是,东欧和中亚地区的EAPCHIV相关DALYsASR最高(14.07%).东部和南部非洲的妇女受艾滋病毒相关宫颈癌的负担最大，而东欧和中亚地区在过去30年中增幅最大。在这些地区，优先推广HPV疫苗接种和对感染艾滋病毒的妇女进行宫颈癌筛查至关重要。
