Abstract：
Secondary epileptogenesis is a theory that hypothesizes that uncontrolled seizures in people with epilepsy lead to the development of new sites of seizure onset. This process has often been cited when people experience a new seizure type after a period of poor seizure control. The theory proposes that repeated seizures induce changes in regions of the brain that are regularly recruited into the seizure. These hypothetical changes can then lead to a new, independent seizure onset zone. The concept is based on a number of clinical observations which secondary epileptogenesis could explain. However there are alternative explanations from the clinic as well as from the laboratory that call the process into question. In this review some of the observations that have been used to support the theory will be reviewed, and the many counterarguments will be presented. At this time there is little evidence to support secondary epileptogenesis and much to refute it.
摘要：
继发性癫痫发生是一种理论，它假设癫痫患者不受控制的癫痫发作导致新的癫痫发作位点的发展。当人们在癫痫发作控制不佳一段时间后出现新的癫痫发作类型时，经常会引用此过程。该理论提出，反复的癫痫发作会引起大脑区域的变化，这些区域经常被招募到癫痫发作中。这些假设的变化会导致新的，独立的癫痫发作区。该概念基于继发性癫痫发生可以解释的许多临床观察。然而，来自诊所和实验室的其他解释使这一过程受到质疑。在这篇综述中，将回顾一些用于支持该理论的观察结果，将提出许多反驳。目前，几乎没有证据支持继发性癫痫发生，也有很多证据可以反驳。
