PDF(Pubmed)
Abstract：
BACKGROUND: Fungal urinary tract infections (UTIs) are becoming increasingly common in hospitalized patients and Candida species are the most prevalent organisms. However, recurrent candiduria in young healthy outpatients is rare thus require further examination to find the etiologic factors.
METHODS: We described a case of recurrent asymptomatic c caused by azole-resistant C. glabrata in a healthy young female who only had previous use of antibiotics without other risk factors. However, after removal of the predisposing factor and the use of sensitive antifungal agents, the patient\'s urine cultures remained positive. This phenomenon indicated to us that the patient might have an immune-related genetic deficiency. We found a novel caspase-associated recruitment domain-containing protein 9 (CARD9) gene mutation (c.808-11G > T) which might be the cause of recurrent asymptomatic candiduria in this immune-competent young female without any underlying diseases.
CONCLUSIONS: We report a case of recurrent asymptomatic candiduria caused by azole-resistant Candida glabrata in a young healthy female with a novel CARD9 mutation. A functional study of this mutation should be performed in the future to determine its effect on asymptomatic fungal UTIs.
METHODS: We described a case of recurrent asymptomatic c caused by azole-resistant C. glabrata in a healthy young female who only had previous use of antibiotics without other risk factors. However, after removal of the predisposing factor and the use of sensitive antifungal agents, the patient\'s urine cultures remained positive. This phenomenon indicated to us that the patient might have an immune-related genetic deficiency. We found a novel caspase-associated recruitment domain-containing protein 9 (CARD9) gene mutation (c.808-11G > T) which might be the cause of recurrent asymptomatic candiduria in this immune-competent young female without any underlying diseases.
CONCLUSIONS: We report a case of recurrent asymptomatic candiduria caused by azole-resistant Candida glabrata in a young healthy female with a novel CARD9 mutation. A functional study of this mutation should be performed in the future to determine its effect on asymptomatic fungal UTIs.
摘要：
背景：真菌尿路感染（UTI）在住院患者中变得越来越普遍，念珠菌是最普遍的生物。然而,年轻健康门诊患者复发性念珠菌很少见，因此需要进一步检查以寻找病因。
方法：我们描述了一例健康的年轻女性，其既往仅使用抗生素而没有其他危险因素，由耐药唑的光滑梭菌引起的复发性无症状c。然而,在去除诱发因素和使用敏感的抗真菌药物后，患者的尿培养保持阳性。这种现象向我们表明患者可能患有免疫相关的遗传缺陷。我们发现了一种新型的含caspase相关募集域的蛋白质9（CARD9）基因突变（c.808-11G>T），这可能是这种免疫能力强的年轻女性复发性无症状念珠菌的原因，没有任何潜在的疾病。
结论：我们报告了一例由耐药唑的光滑念珠菌引起的复发性无症状念珠菌，在一名年轻的健康女性中出现了新的CARD9突变。将来应该对这种突变进行功能研究，以确定其对无症状真菌UTI的影响。
方法：我们描述了一例健康的年轻女性，其既往仅使用抗生素而没有其他危险因素，由耐药唑的光滑梭菌引起的复发性无症状c。然而,在去除诱发因素和使用敏感的抗真菌药物后，患者的尿培养保持阳性。这种现象向我们表明患者可能患有免疫相关的遗传缺陷。我们发现了一种新型的含caspase相关募集域的蛋白质9（CARD9）基因突变（c.808-11G>T），这可能是这种免疫能力强的年轻女性复发性无症状念珠菌的原因，没有任何潜在的疾病。
结论：我们报告了一例由耐药唑的光滑念珠菌引起的复发性无症状念珠菌，在一名年轻的健康女性中出现了新的CARD9突变。将来应该对这种突变进行功能研究，以确定其对无症状真菌UTI的影响。
