PDF(Pubmed)
Abstract：
UNASSIGNED: Parkinsonism and akinetic mutism (AM) following ventriculo-peritoneal shunt (VPS) without underdrainage used to be considered rare, but may be underdiagnosed in daily clinical practice. Although the pathophysiology is still unclear, in several case reports, the parkinsonism and AM after VPS shows responsiveness to dopaminergic treatment.
UNASSIGNED: We report a 19-year-old male that presented with severe parkinsonism and AM after VPS. Meanwhile, 18F-FDG-PET showed a cortical and subcortical hypometabolism. Fortunately, levodopa dramatically improved patient\'s symptoms and brain hypometabolism. This report provides support for the possibility that dopamine deficiency inhibits brain metabolism, and further elucidates the pathogenesis of parkinsonism and AM.
UNASSIGNED: This report highlights the presentation of a treatable parkinsonism and points out that Levodopa and/or dopamine agonist should be the first choice if the patients develop parkinson-like symptoms after VPS.
UNASSIGNED: We report a 19-year-old male that presented with severe parkinsonism and AM after VPS. Meanwhile, 18F-FDG-PET showed a cortical and subcortical hypometabolism. Fortunately, levodopa dramatically improved patient\'s symptoms and brain hypometabolism. This report provides support for the possibility that dopamine deficiency inhibits brain metabolism, and further elucidates the pathogenesis of parkinsonism and AM.
UNASSIGNED: This report highlights the presentation of a treatable parkinsonism and points out that Levodopa and/or dopamine agonist should be the first choice if the patients develop parkinson-like symptoms after VPS.
摘要：
■脑室-腹腔分流术（VPS）后的帕金森综合征和运动障碍默症（AM）过去被认为是罕见的，但在日常临床实践中可能被低估。尽管病理生理学尚不清楚，在几个病例报告中，VPS后的帕金森病和AM对多巴胺能治疗有反应性。
■我们报告了一名19岁男性，在VPS后出现严重的帕金森病和AM。同时,18F-FDG-PET显示皮质和皮质下低代谢。幸运的是,左旋多巴显著改善患者的症状和大脑代谢低下。该报告为多巴胺缺乏抑制大脑代谢的可能性提供了支持，并进一步阐明了帕金森病和AM的发病机制。
■本报告重点介绍了可治疗的帕金森病，并指出，如果患者在VPS后出现帕金森病样症状，左旋多巴和/或多巴胺激动剂应该是首选。
■我们报告了一名19岁男性，在VPS后出现严重的帕金森病和AM。同时,18F-FDG-PET显示皮质和皮质下低代谢。幸运的是,左旋多巴显著改善患者的症状和大脑代谢低下。该报告为多巴胺缺乏抑制大脑代谢的可能性提供了支持，并进一步阐明了帕金森病和AM的发病机制。
■本报告重点介绍了可治疗的帕金森病，并指出，如果患者在VPS后出现帕金森病样症状，左旋多巴和/或多巴胺激动剂应该是首选。
