PDF(Pubmed)
Abstract：
UNASSIGNED: Calcium Hydroxylapatite (CaHA) is a common dermal filler used in aesthetic medicine for volumizing and contouring. Understanding mechanisms of actions of CaHA can help improve our understanding of its clinical applications.
UNASSIGNED: We performed a systematic review to summarize the skin-regeneration related mechanisms of CaHA. Five bibliographic databases were searched for English-language publications that evaluated CaHA in skin regeneration outcomes including neocollagenesis, cell proliferation and growth factors, angiogenesis, vascular dynamic and inflammatory markers, among others. Methodological rigor of included studies was assessed.
UNASSIGNED: Of 2,935 identified citations, 12 studies were included for final analysis. Collagen production was reported by nine studies, cell proliferation by four, elastic fibers and/or elastin by four, and three studies on angiogenesis, while limited studies were available on the other outcomes. Six were clinical/observational studies. Only seven studies had a control group. Overall, studies showed CaHA resulted in increased cell proliferation, increased collagen production and angiogenesis, as well as in higher elastic fiber and elastin formation. Limited and inconclusive evidence was available on the other mechanisms. The majority of the studies had methodological limitations.
UNASSIGNED: Current evidence is limited but indicates several mechanisms through which CaHA could lead to skin regeneration, volume enhancement, and contouring.
UNASSIGNED: https://doi.org/10.17605/OSF.IO/WY49V.
UNASSIGNED: We performed a systematic review to summarize the skin-regeneration related mechanisms of CaHA. Five bibliographic databases were searched for English-language publications that evaluated CaHA in skin regeneration outcomes including neocollagenesis, cell proliferation and growth factors, angiogenesis, vascular dynamic and inflammatory markers, among others. Methodological rigor of included studies was assessed.
UNASSIGNED: Of 2,935 identified citations, 12 studies were included for final analysis. Collagen production was reported by nine studies, cell proliferation by four, elastic fibers and/or elastin by four, and three studies on angiogenesis, while limited studies were available on the other outcomes. Six were clinical/observational studies. Only seven studies had a control group. Overall, studies showed CaHA resulted in increased cell proliferation, increased collagen production and angiogenesis, as well as in higher elastic fiber and elastin formation. Limited and inconclusive evidence was available on the other mechanisms. The majority of the studies had methodological limitations.
UNASSIGNED: Current evidence is limited but indicates several mechanisms through which CaHA could lead to skin regeneration, volume enhancement, and contouring.
UNASSIGNED: https://doi.org/10.17605/OSF.IO/WY49V.
摘要：
■钙羟基磷灰石(CaHA)是在美容医学中用于体积化和轮廓化的常见真皮填充剂。了解CaHA的作用机制有助于提高我们对其临床应用的理解。
■我们进行了系统综述，以总结CaHA的皮肤再生相关机制。搜索了五个书目数据库，以获取评估CaHA在皮肤再生结果中的英文出版物，包括新生，细胞增殖和生长因子，血管生成,血管动力学和炎症标志物，在其他人中。评估纳入研究的方法学严谨性。
■在2,935个确定的引文中，包括12项研究进行最终分析。九项研究报告了胶原蛋白的产生，细胞增殖由四个，弹性纤维和/或弹性蛋白由四个，和三项关于血管生成的研究，而其他结局的研究有限。六项是临床/观察性研究。只有7项研究有对照组。总的来说,研究表明，CaHA导致细胞增殖增加，增加胶原蛋白的产生和血管生成，以及更高的弹性纤维和弹性蛋白的形成。其他机制提供的证据有限且不确定。大多数研究都有方法学上的局限性。
■目前的证据有限，但表明了几种机制，通过这些机制，CaHA可以导致皮肤再生，音量增强,和轮廓。
■https://doi.org/10.17605/OSF。IO/WY49V。
■我们进行了系统综述，以总结CaHA的皮肤再生相关机制。搜索了五个书目数据库，以获取评估CaHA在皮肤再生结果中的英文出版物，包括新生，细胞增殖和生长因子，血管生成,血管动力学和炎症标志物，在其他人中。评估纳入研究的方法学严谨性。
■在2,935个确定的引文中，包括12项研究进行最终分析。九项研究报告了胶原蛋白的产生，细胞增殖由四个，弹性纤维和/或弹性蛋白由四个，和三项关于血管生成的研究，而其他结局的研究有限。六项是临床/观察性研究。只有7项研究有对照组。总的来说,研究表明，CaHA导致细胞增殖增加，增加胶原蛋白的产生和血管生成，以及更高的弹性纤维和弹性蛋白的形成。其他机制提供的证据有限且不确定。大多数研究都有方法学上的局限性。
■目前的证据有限，但表明了几种机制，通过这些机制，CaHA可以导致皮肤再生，音量增强,和轮廓。
■https://doi.org/10.17605/OSF。IO/WY49V。
