METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus, up to 31 December 2022. Data were expressed as standardized mean difference with 95 % confidence intervals. The I2 index was employed to evaluate heterogeneity.
RESULTS: Six studies were included in the qualitative and quantitative analysis, with a total of 18,291 post-menopausal women. Compared with women of normal age at menopause (>45 years), women with early menopause demonstrated lower muscle mass, assessed by appendicular skeletal muscle mass/body mass index [standardized mean difference (SMD) -0.14, 95 % confidence interval (CI) -0.20 to -0.07, p < 0.001; I2 0%]. However, no differences in muscle strength, assessed by handgrip strength (SMD -0.15, 95 % CI -0.31 to 0.01, p = 0.071; I2 72%), and muscle performance, assessed by gait speed (SMD -0.11, 95 % CI -0.29 to 0.05, p = 0.18; I2 79%), were found. Women with premature ovarian insufficiency had lower handgrip strength (SMD -0.3, 95 % CI -0.58 to -0.01, p = 0.04; I2 74.6 %) and gait speed (SMD -0.13, 95 % CI -0.23 to -0.04, p = 0.004; I2 0%) compared with women of normal age at menopause.
CONCLUSIONS: Early menopause is associated with reduced muscle mass and premature ovarian insufficiency with reduced muscle strength and performance compared with normal age at menopause.
方法:在PubMed中进行了全面搜索,CENTRAL和Scopus,至2022年12月31日。数据表示为具有95%置信区间的标准化平均差。采用I2指数评价异质性。
结果:六项研究纳入了定性和定量分析,共有18,291名绝经后妇女。与正常年龄(>45岁)的绝经期妇女相比,绝经早期的女性肌肉质量较低,通过阑尾骨骼肌质量/体重指数评估[标准化平均差(SMD)-0.14,95%置信区间(CI)-0.20至-0.07,p<0.001;I20%]。然而,肌肉力量没有差异,按握力评估(SMD-0.15,95%CI-0.31至0.01,p=0.071;I272%),和肌肉表现,通过步态速度评估(SMD-0.11,95%CI-0.29至0.05,p=0.18;I279%),被发现了。与绝经时正常年龄的女性相比,过早卵巢功能不全的女性的握力较低(SMD-0.3,95%CI-0.58至-0.01,p=0.04;I274.6%)和步态速度较低(SMD-0.13,95%CI-0.23至-0.04,p=0.004;I20%)。
结论:与绝经时的正常年龄相比,早期绝经与肌肉量减少和过早卵巢功能不全相关,肌肉力量和表现降低。