Abstract：
This experiment was carried out to investigate the effect of combined treatment of tubal obstruction infertility with deacetylated chitosan and two microscopes on the levels of IFN-γ and ICAM-1. In this study, 100 infertile patients with fallopian tube obstruction who were treated in Jiangbei District Hospital of traditional Chinese medicine from January to August 2019 were divided into two groups according to the alternating grouping method, group A (50 cases) received combined surgery, and Group B (50 cases) received combined surgery and chitosan. The curative effect and postoperative pelvic adhesion of the two groups were analyzed, and the levels of IFN-γ, ICAM-1 and IL6(IL-6), laminin (LN), Transforming growth factor beta 1(TGF-β1) and fibronectin (FN) were observed before and after treatment. Results showed that the total effective rate of Group B was higher than that of Group A (92. 00% vs 76. 00%). The incidence of pelvic adhesion was lower in Group A (4. 00% vs 16. 00%) (P < 0.05). The levels of IFN-γ, ICAM-1, IL-6, LN, FN and TGF-β1 in Group B were significantly lower than those in group A (P < 0.05). In conclusion, the treatment of tubal obstruction infertility with combined deacetylated chitosan and biendoscopy is effective, which can reduce the levels of IFN-γ and ICAM-1, improve the expression of adhesion-related factors and reduce the occurrence of pelvic adhesion.
摘要：
本实验旨在探讨脱乙酰壳聚糖联合两种显微镜治疗输卵管阻塞性不孕症对IFN-γ和ICAM-1水平的影响。在这项研究中,选取江北区中医医院2019年1-8月收治的输卵管阻塞不孕患者100例，按交替分组法分为两组，A组50例接受联合手术,B组（50例）接受联合手术和壳聚糖。分析两组患者的疗效及术后盆腔粘连情况,和IFN-γ的水平，ICAM-1和IL6（IL-6），层粘连蛋白(LN),观察治疗前后转化生长因子β1（TGF-β1）和纤连蛋白（FN）的变化。成果显示B组总有效率高于A组(92。00%vs76。00%）。A组盆腔粘连发生率较低(4.00%vs16。00%)(P<0.05)。IFN-γ的水平，ICAM-1,IL-6,LN,B组FN、TGF-β1明显低于A组(P<0.05)。总之,脱乙酰壳聚糖联合生物内镜治疗输卵管阻塞性不孕症有效,可以降低IFN-γ和ICAM-1水平,提高粘连相关因子的表达,减少盆腔粘连的发生。
