Abstract：
Fine needle aspirations are infrequently performed on the spleen due to concerns for hemorrhagic complications. As a result, splenic lesions can be challenging to diagnose given the limited amount of available specimen. Metastasis to the spleen is rare and metastatic neuroendocrine tumors to the spleen are scarce in literature. The diagnosis of splenic lesions from fine needle aspirate entails processing which prolongs the turnaround time, particularly if the cytomorphology is non-typical and a limited sample can further complicate this process. We describe a case in which flow cytometry performed on fine needle aspiration of a splenic lesion suggested a diagnosis of neuroendocrine neoplasm involving the spleen. Further workup confirmed this diagnosis. Flow cytometry can recognize neuroendocrine tumors involving the spleen in a timely manner so that appropriate immunohistochemistry tests on limited specimens can be performed to aid in their accurate diagnosis.
摘要：
由于担心出血性并发症，很少在脾脏上进行细针穿刺。因此,鉴于可用标本数量有限，脾病变的诊断可能具有挑战性。脾脏的转移很少见，而脾脏的转移性神经内分泌肿瘤在文献中很少见。通过细针抽吸术诊断脾病变需要进行处理，从而延长了周转时间。特别是如果细胞形态学是非典型的，并且有限的样品会使该过程进一步复杂化。我们描述了一种情况，其中对脾病变的细针抽吸进行流式细胞术提示诊断为涉及脾脏的神经内分泌肿瘤。进一步的检查证实了这一诊断。流式细胞术可以及时识别涉及脾脏的神经内分泌肿瘤，从而可以对有限的标本进行适当的免疫组织化学测试，以帮助其准确诊断。
