Abstract：
BACKGROUND: Acute or chronic HBV infection in an individual can be laboratory characterized according to the serological profile of the viral markers in the bloodstream, and the dynamics monitoring of these markers is necessary to assess the disorder course and the infection outcome. However, under certain circumstances unusual or atypical serological profiles may be observed in both acute and chronic HBV infection. They are considered as such because they do not properly characterize the form or infection clinical phase or because they seem inconsistent, considering the viral markers dynamics in both clinical contexts. This manuscript comprises the analysis of an unusual serological profile in HBV infection.
RESULTS: This clinical-laboratory study, had as reference a patient who presented clinical profile suggestive of acute HBV infection after recent exposure, whose laboratory data were initially compatible with this clinical presentation. However, the serological profile analysis and its monitoring demonstrated unusual pattern of viral markers expression, which has been observed in several clinical contexts, and is often associated a number of agent- or host-related factors.
CONCLUSIONS: The serological profile analyzed here, associated with the biochemical markers serum levels found, is indicative of active chronic infection, consequence of viral reactivation. This finding suggests that in the event of unusual serological profiles in HBV infection, if the influence of agent- or host-related factors is not properly considered and neither the viral markers dynamics properly analyzed, there may be mistake in the infection clinical diagnosis, especially when the patient\'s clinical and epidemiological history is unknown.
RESULTS: This clinical-laboratory study, had as reference a patient who presented clinical profile suggestive of acute HBV infection after recent exposure, whose laboratory data were initially compatible with this clinical presentation. However, the serological profile analysis and its monitoring demonstrated unusual pattern of viral markers expression, which has been observed in several clinical contexts, and is often associated a number of agent- or host-related factors.
CONCLUSIONS: The serological profile analyzed here, associated with the biochemical markers serum levels found, is indicative of active chronic infection, consequence of viral reactivation. This finding suggests that in the event of unusual serological profiles in HBV infection, if the influence of agent- or host-related factors is not properly considered and neither the viral markers dynamics properly analyzed, there may be mistake in the infection clinical diagnosis, especially when the patient\'s clinical and epidemiological history is unknown.
摘要：
背景：个体的急性或慢性HBV感染可以根据血液中病毒标志物的血清学特征进行实验室表征，这些标志物的动态监测对于评估疾病病程和感染结局是必要的。然而,在某些情况下，在急性和慢性HBV感染中可能观察到异常或非典型的血清学特征。它们被认为是这样的，因为它们不能正确表征形式或感染临床阶段，或者因为它们看起来不一致，考虑两种临床环境中的病毒标志物动态。该手稿包括对HBV感染中异常血清学特征的分析。
结果：本临床实验室研究，作为参考的患者提出的临床资料提示急性HBV感染后，最近的暴露，其实验室数据最初与该临床表现相符。然而,血清学谱分析及其监测显示了病毒标记表达的异常模式，这在几种临床环境中已经观察到，并且通常与许多与代理或宿主相关的因素有关。
结论：此处分析的血清学概况，与发现的生化标志物血清水平相关，表明活动性慢性感染，病毒再激活的结果。这一发现表明，在HBV感染的异常血清学特征的事件，如果没有适当考虑试剂或宿主相关因素的影响，并且没有适当分析病毒标志物的动力学，感染的临床诊断可能会有错误,特别是当患者的临床和流行病学史是未知的。
结果：本临床实验室研究，作为参考的患者提出的临床资料提示急性HBV感染后，最近的暴露，其实验室数据最初与该临床表现相符。然而,血清学谱分析及其监测显示了病毒标记表达的异常模式，这在几种临床环境中已经观察到，并且通常与许多与代理或宿主相关的因素有关。
结论：此处分析的血清学概况，与发现的生化标志物血清水平相关，表明活动性慢性感染，病毒再激活的结果。这一发现表明，在HBV感染的异常血清学特征的事件，如果没有适当考虑试剂或宿主相关因素的影响，并且没有适当分析病毒标志物的动力学，感染的临床诊断可能会有错误,特别是当患者的临床和流行病学史是未知的。
