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Abstract：
This observational study aimed to determine whether individuals with fibromyalgia (FM) exhibit higher levels of neuroinflammation than healthy controls (HCs), as measured with positron emission tomography using [ 18 F]DPA-714, a second-generation radioligand for the translocator protein (TSPO). Fifteen women with FM and 10 HCs underwent neuroimaging. Distribution volume (V T ) was calculated for in 28 regions of interest (ROIs) using Logan graphical analysis and compared between groups using multiple linear regressions. Group (FM vs HC) was the main predictor of interest and TSPO binding status (high- vs mixed-affinity) was added as a covariate. The FM group had higher V T in the right postcentral gyrus ( b = 0.477, P = 0.033), right occipital gray matter (GM; b = 0.438, P = 0.039), and the right temporal GM ( b = 0.466, P = 0.042). The FM group also had lower V T than HCs in the left isthmus of the cingulate gyrus ( b = -0.553, P = 0.014). In the subgroup of high-affinity binders, the FM group had higher V T in the bilateral precuneus, postcentral gyrus, parietal GM, occipital GM, and supramarginal gyrus. Group differences in the right parietal GM were associated with decreased quality of life, higher pain severity and interference, and cognitive problems. In support of our hypothesis, we found increased radioligand binding (V T ) in the FM group compared with HCs in several brain regions regardless of participants\' TSPO binding status. The ROIs overlapped with prior reports of increased TSPO binding in FM. Overall, increasing evidence supports the hypothesis that FM involves microglia-mediated neuroinflammation in the brain.
摘要：
■这项观察性研究旨在确定纤维肌痛（FM）患者的神经炎症水平是否高于健康对照（HC）。如使用[18F]DPA-714的正电子发射断层扫描测量的，DPA-714是转运蛋白（TSPO）的第二代放射性配体。15名FM和10名HCs的女性接受了神经影像学检查。使用Logan图形分析计算28个感兴趣区域（ROI）的分布体积（VT），并使用多重线性回归进行组间比较。组(FMvsHC)是感兴趣的主要预测因子,并且添加TSPO结合状态(高vs混合亲和力)作为协变量。FM组右中央后回VT较高(b=0.477,P=0.033),右枕骨灰质(GM;b=0.438,P=0.039),和右时间GM（b=0.466，P=0.042）。FM组在扣带回左峡部的VT也低于HC（b=-0.553，P=0.014）。在高亲和力结合子组中，FM组双侧前肌室性心动过速较高,中央后回,顶叶GM,枕骨GM,和颈上回。右侧顶叶GM的组差异与生活质量下降有关，较高的疼痛严重程度和干扰，和认知问题。为了支持我们的假设，我们发现,无论参与者的TSPO结合状态如何,与多个脑区的HC相比,FM组的放射性配体结合(VT)增加.ROI与FM中TSPO结合增加的先前报道重叠。总的来说,越来越多的证据支持以下假设：FM涉及小胶质细胞介导的脑神经炎症。
