Abstract：
Synthetic polymers are indispensable in biomedical applications because they can be fabricated with consistent and reproducible properties, facile scalability, and customizable functionality to perform diverse tasks. However, currently available synthetic polymers have limitations, most notably when timely biodegradation is required. Despite there being, in principle, an entire periodic table to choose from, with the obvious exception of silicones, nearly all known synthetic polymers are combinations of carbon, nitrogen, and oxygen in the main chain. Expanding this to main-group heteroatoms can open the way to novel material properties. Herein the authors report on research to incorporate the chemically versatile and abundant silicon and phosphorus into polymers to induce cleavability into the polymer main chain. Less stable polymers, which degrade in a timely manner in mild biological environments, have considerable potential in biomedical applications. Herein the basic chemistry behind these materials is described and some recent studies into their medical applications are highlighted.
摘要：
合成聚合物在生物医学应用中是不可或缺的，因为它们可以制造出具有一致和可重复的特性，方便的可扩展性，和可定制的功能来执行不同的任务。然而,目前可用的合成聚合物有局限性，最值得注意的是，当需要及时生物降解时。尽管有,原则上,整个周期表可供选择，除了有机硅之外，几乎所有已知的合成聚合物都是碳的组合，主链中的氮和氧。将其扩展到主族杂原子可以为新的材料特性开辟道路。在此，我们报告了将化学上通用且丰富的硅和磷掺入聚合物中以诱导聚合物主链的可裂解性的研究。不太稳定的聚合物，在温和的生物环境中及时降解，在生物医学应用中具有相当大的潜力。在这里，我们描述了这些材料背后的基本化学，并重点介绍了一些有关其医学应用的最新研究。本文受版权保护。保留所有权利。
