Abstract:
The sickle cell disease (SCD) population has been considered particularly vulnerable to viral pandemics since the emergence of H1N1 in 2009. In this sense, the advance of the COVID-19 pandemic from 2020 has brought this group of patients to the center of concern. However, scientific knowledge about the susceptibility of patients with SCD to a severe COVID-19 pandemic is still insufficient, and efforts to establish a general profile of the disease in these patients, remain inadequate. The present study, therefore, sought to characterize the case fatality rate and severity of COVID-19 in patients with SCD throughout the world. A systematic review of Pubmed/MEDLINE, Scopus, Cochrane Library, and Virtual Health Library databases through December 2021 was then performed. Subsequently, the primary and secondary outcomes were used in the meta-analysis in RStudio® software. Seventy-two studies were included with 6,011 SCD patients confirmed to have SARS-CoV-2 infection between mid-2020 and early 2022. The mean age of patients was 27 years. During this period, 218 deaths caused by COVID-19 were reported in the studied population, corresponding to an overall case fatality rate of 3%. In addition, 10% of patients with SCD were admitted to the ICU after complications caused by COVID-19, and 4% of them required invasive ventilatory support. In conclusion, the high fatality rate, intensive care unit admission and need for mechanical ventilation due to COVID-19 in young patients with SCD indicate that this population is at high risk for severe disease progression.
摘要:
自2009年H1N1出现以来,镰状细胞病(SCD)人群被认为特别容易受到病毒大流行的影响。在这个意义上,2020年COVID-19大流行的进展使这组患者成为关注的中心。然而,关于SCD患者对严重COVID-19大流行的易感性的科学知识仍然不足,并努力确定这些患者的疾病概况,保持不足。本研究,因此,试图描述世界各地SCD患者中COVID-19的病死率和严重程度。对Pubmed/MEDLINE的系统评价,Scopus,科克伦图书馆,然后执行到2021年12月的虚拟健康图书馆数据库。随后,在RStudio®软件的荟萃分析中使用了主要和次要结局.纳入72项研究,纳入6,011名SCD患者,确认在2020年中期至2022年初感染SARS-CoV-2。患者的平均年龄为27岁。在此期间,在研究人群中报告了由COVID-19导致的218例死亡,相当于3%的总病死率。此外,10%的SCD患者在COVID-19引起的并发症后进入ICU,其中4%的患者需要有创通气支持。总之,高死亡率,年轻SCD患者因COVID-19而入院重症监护病房和需要机械通气表明,该人群存在严重疾病进展的高风险.