PDF(Pubmed)
Abstract：
Numerous physiological processes occur following bone fracture, including inflammatory cell recruitment, vascularization, and callus formation and remodeling. In particular circumstances, such as critical bone defects or osteonecrosis, the regenerative microenvironment is compromised, rendering endogenous stem/progenitor cells incapable of fully manifesting their reparative potential. Consequently, external interventions, such as grafting or augmentation, are frequently necessary. In situ bone tissue engineering (iBTE) employs cell-free scaffolds that possess microenvironmental cues, which, upon implantation, redirect the behavior of endogenous stem/progenitor cells towards a pro-regenerative inflammatory response and reestablish angiogenesis-osteogenesis coupling. This process ultimately results in vascularized bone regeneration (VBR). In this context, a comprehensive review of the current techniques and modalities in VBR-targeted iBTE technology is provided.
摘要：
骨折后发生许多生理过程，包括炎症细胞募集，血管化,愈伤组织的形成和重塑。在特殊情况下,如严重的骨缺损或骨坏死，再生微环境受到损害，使内源性干/祖细胞不能完全显示其修复潜力。因此,外部干预,如移植或增强，往往是必要的。原位骨组织工程（iBTE）采用具有微环境线索的无细胞支架，which,植入后，将内源性干/祖细胞的行为重定向到促再生炎症反应并重建血管生成-骨生成偶联。该过程最终导致血管化骨再生(VBR)。在这种情况下，提供了针对VBR靶向iBTE技术的当前技术和模式的全面回顾。
