PDF(Pubmed)
Abstract：
Abrikossoff tumors, also known as granular cell tumors (GCT), originate from Schwann cells. The most common location is in the oral cavity, followed by the skin, but they can also be found in the breast, digestive tract, tracheobronchial tree, or central nervous system. They can affect both sexes at any age, with a higher incidence between 30 and 50 years and a slight predisposition for female sex. They are usually solitary tumors but may also be multifocal. Most of the time, they are benign, with malignancy being exceptional in <2% of cases. Clinically, they appear as solid, well-defined, painless tumors, located subcutaneously with dimensions that can reach up to 10 cm. The definitive diagnosis is based on the immunohistochemical examination, and the treatment for benign tumors consists of surgical excision. Chemotherapy or radiotherapy may be required for malignant lesions, but the treatment regimens and their benefits remain unclear. This manuscript presents the case of a 12-year-old girl with a benign GCT, located in the skin on the mandibular line.
摘要：
Abrikossoff肿瘤,也被称为颗粒细胞瘤（GCT），起源于雪旺氏细胞。最常见的位置是口腔，其次是皮肤，但它们也可以在乳房中找到，消化道，气管支气管树，或中枢神经系统。它们可以在任何年龄影响两性，在30至50岁之间的发病率较高，并且对女性有轻微的易感性。它们通常是孤立性肿瘤，但也可能是多灶性肿瘤。大多数时候,它们是良性的，恶性肿瘤在<2%的病例中是例外的。临床上,它们看起来像固体，定义明确，无痛性肿瘤，位于皮下，尺寸可达10厘米。最终诊断基于免疫组织化学检查，良性肿瘤的治疗包括手术切除。恶性病变可能需要化疗或放疗，但治疗方案及其获益尚不清楚.这份手稿展示了一个12岁女孩患有良性GCT的案例，位于下颌线上的皮肤上。
