PDF(Pubmed)
Abstract：
BACKGROUND: Pain is a major symptom in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome. Although the underlying mechanism causing generalized pain in children with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome is unclear, central sensitization has been suggested as a possible explanation. The aim of this study was to explore the feasibility of a study protocol for a future case-control study, investigating features of central sensitization in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome.
METHODS: Central sensitization features were measured in ten patients and nine healthy controls aged 13-17 years via experimental pain measurement quantifying primary and secondary hyperalgesia, endogenous pain modulation, and exercise-induced hyperalgesia. Descriptive statistics were used. Frequency, median, and range values were calculated.
RESULTS: Eleven out of 57 patients chose to participate. No control could be recruited through public schools. Therefore, a convenience sampling strategy was used for the recruitment of the control group. The process of assessing primary and secondary hyperalgesia, endogenous pain modulation, and exercise-induced hyperalgesia was well tolerated by all participants (patients and controls). When assessing endogenous pain modulation via conditioned pain modulation, two participants in the patient group and three in the control group did not achieve a pain experience ≥ 3 on the numerical rating scale when immersing their hands in cold water.
CONCLUSIONS: This study investigated the feasibility, safety, and toleration of experimental pain measurements in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome. Although the test protocol proved to be sufficiently feasible for use with the participant group, it will need to be adapted in the main study in order to obtain more reliable data. Recruitment, especially of participants for the control group, can be a major obstacle for future studies and requires careful planning.
BACKGROUND: Researchweb.org, 270,501. Registered on 9 May 2019.
METHODS: Central sensitization features were measured in ten patients and nine healthy controls aged 13-17 years via experimental pain measurement quantifying primary and secondary hyperalgesia, endogenous pain modulation, and exercise-induced hyperalgesia. Descriptive statistics were used. Frequency, median, and range values were calculated.
RESULTS: Eleven out of 57 patients chose to participate. No control could be recruited through public schools. Therefore, a convenience sampling strategy was used for the recruitment of the control group. The process of assessing primary and secondary hyperalgesia, endogenous pain modulation, and exercise-induced hyperalgesia was well tolerated by all participants (patients and controls). When assessing endogenous pain modulation via conditioned pain modulation, two participants in the patient group and three in the control group did not achieve a pain experience ≥ 3 on the numerical rating scale when immersing their hands in cold water.
CONCLUSIONS: This study investigated the feasibility, safety, and toleration of experimental pain measurements in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome. Although the test protocol proved to be sufficiently feasible for use with the participant group, it will need to be adapted in the main study in order to obtain more reliable data. Recruitment, especially of participants for the control group, can be a major obstacle for future studies and requires careful planning.
BACKGROUND: Researchweb.org, 270,501. Registered on 9 May 2019.
摘要：
背景：疼痛是青少年高移动谱系障碍或超移动Ehlers-Danlos综合征的主要症状。尽管导致高移动谱系障碍或高移动Ehlers-Danlos综合征儿童全身疼痛的潜在机制尚不清楚，中央敏化已被建议作为一种可能的解释。这项研究的目的是探索未来病例对照研究的研究方案的可行性，调查青少年高移动频谱障碍或超移动Ehlers-Danlos综合征的中枢致敏特征。
方法：通过实验性疼痛测量量化原发性和继发性痛觉过敏，在10名13-17岁的患者和9名健康对照中测量了中枢致敏特征，内源性疼痛调节，和运动引起的痛觉过敏。使用描述性统计。频率,中位数，并计算了范围值。
结果：57名患者中有11人选择参加。无法通过公立学校招募控制权。因此,对照组的招募采用便利抽样策略.评估原发性和继发性痛觉过敏的过程，内源性疼痛调节，所有参与者(患者和对照组)对运动性痛觉过敏的耐受性良好.当通过条件性疼痛调制评估内源性疼痛调制时，患者组的两名参与者和对照组的三名参与者在将手浸入冷水中时,在数字评定量表上未达到≥3的疼痛体验.
结论：这项研究调查了可行性，安全,以及对患有高移动频谱障碍或高移动Ehlers-Danlos综合征的青少年的实验性疼痛测量的耐受性。尽管测试方案被证明对于与参与者组一起使用是足够可行的，为了获得更可靠的数据，需要在主要研究中进行调整。招聘,尤其是对照组的参与者，可能是未来研究的主要障碍，需要仔细规划。
背景：Researchweb.org，270,501。2019年5月9日注册
方法：通过实验性疼痛测量量化原发性和继发性痛觉过敏，在10名13-17岁的患者和9名健康对照中测量了中枢致敏特征，内源性疼痛调节，和运动引起的痛觉过敏。使用描述性统计。频率,中位数，并计算了范围值。
结果：57名患者中有11人选择参加。无法通过公立学校招募控制权。因此,对照组的招募采用便利抽样策略.评估原发性和继发性痛觉过敏的过程，内源性疼痛调节，所有参与者(患者和对照组)对运动性痛觉过敏的耐受性良好.当通过条件性疼痛调制评估内源性疼痛调制时，患者组的两名参与者和对照组的三名参与者在将手浸入冷水中时,在数字评定量表上未达到≥3的疼痛体验.
结论：这项研究调查了可行性，安全,以及对患有高移动频谱障碍或高移动Ehlers-Danlos综合征的青少年的实验性疼痛测量的耐受性。尽管测试方案被证明对于与参与者组一起使用是足够可行的，为了获得更可靠的数据，需要在主要研究中进行调整。招聘,尤其是对照组的参与者，可能是未来研究的主要障碍，需要仔细规划。
背景：Researchweb.org，270,501。2019年5月9日注册
