PDF(Pubmed)
Abstract：
Itch is a distinctive sensation that causes a specific affection and scratching reaction. The anterior cingulate cortex (ACC) has been linked to itch sensation in numerous studies; however, its precise function in processing pruritic inputs remains unknown. Distinguishing the precise role of the ACC in itch sensation can be challenging because of its capacity to conduct heterologous neurophysiological activities. Here, we used in vivo calcium imaging to examine how ACC neurons in free-moving mice react to pruritogenic histamine. In particular, we focused on how the activity of the ACC neurons varied before and after the scratching response. We discovered that although the change in neuronal activity was not synchronized with the scratching reaction, the overall activity of itch-responsive neurons promptly decreased after the scratching response. These findings suggest that the ACC does not directly elicit the feeling of itchiness.
摘要：
瘙痒是一种独特的感觉，会引起特定的感情和抓挠反应。在许多研究中，前扣带皮层（ACC）与瘙痒感有关；然而，它在处理瘙痒输入中的精确功能仍然未知。区分ACC在瘙痒感觉中的精确作用可能是具有挑战性的,因为其进行异源神经生理活动的能力。这里,我们使用体内钙成像来检查自由移动小鼠的ACC神经元对致痒组胺的反应。特别是,我们专注于ACC神经元的活动在抓挠反应前后的变化。我们发现，尽管神经元活动的变化与抓挠反应不同步，瘙痒反应神经元的整体活性在抓挠反应后迅速下降。这些发现表明ACC不会直接引起发痒的感觉。
