Abstract：
BACKGROUND: The role of contact sensitisation in the pathogenesis of oral lichen planus (OLP) has not been clearly defined.
OBJECTIVE: We aimed to evaluate relevant contact sensitisers in OLP.
METHODS: A retrospective study was conducted on OLP patients who underwent patch testing from 1 January 2006 to 31 December 2020 at an Australian tertiary dermatology institution, compared to cheilitis patients patch tested over the same time period.
RESULTS: Ninety-six OLP patients and 152 cheilitis patients were patch tested during the 15-year period. Seventy-one (73.9%) OLP patients and 100 (65.8%) cheilitis patients recorded one or more relevant reactions. Forty-three (44.8%), 22 (22.9%), 21 (21.9%) and 17 (17.7%) OLP patients had relevant reactions to mercury-related chemicals, amalgam, spearmint and carvone, respectively, compared to 6 (3.9%), 3 (2.0%), 4 (2.6%) and 0 (0%) cheilitis patients, respectively (p-value <0.001 each). Four (4.2%) OLP patients had relevant positive reactions to sodium metabisulfite, compared to none in the cheilitis group (p-value 0.021).
CONCLUSIONS: While dental amalgam is used less frequently these days, we report that mercury (found in amalgam) and additionally spearmint and carvone are relevant sensitisers in OLP in Australia. Sodium metabisulfite may also be a relevant sensitiser in OLP, which has not previously been reported.
OBJECTIVE: We aimed to evaluate relevant contact sensitisers in OLP.
METHODS: A retrospective study was conducted on OLP patients who underwent patch testing from 1 January 2006 to 31 December 2020 at an Australian tertiary dermatology institution, compared to cheilitis patients patch tested over the same time period.
RESULTS: Ninety-six OLP patients and 152 cheilitis patients were patch tested during the 15-year period. Seventy-one (73.9%) OLP patients and 100 (65.8%) cheilitis patients recorded one or more relevant reactions. Forty-three (44.8%), 22 (22.9%), 21 (21.9%) and 17 (17.7%) OLP patients had relevant reactions to mercury-related chemicals, amalgam, spearmint and carvone, respectively, compared to 6 (3.9%), 3 (2.0%), 4 (2.6%) and 0 (0%) cheilitis patients, respectively (p-value <0.001 each). Four (4.2%) OLP patients had relevant positive reactions to sodium metabisulfite, compared to none in the cheilitis group (p-value 0.021).
CONCLUSIONS: While dental amalgam is used less frequently these days, we report that mercury (found in amalgam) and additionally spearmint and carvone are relevant sensitisers in OLP in Australia. Sodium metabisulfite may also be a relevant sensitiser in OLP, which has not previously been reported.
摘要：
背景：接触致敏在口腔扁平苔藓（OLP）发病机理中的作用尚未明确定义。
目的：我们旨在评估OLP中相关的接触致敏剂。
方法：对2006年1月1日至2020年12月31日在澳大利亚三级皮肤病学机构接受斑贴测试的OLP患者进行了回顾性研究，与同期测试的唇炎患者相比。
结果：在15年期间对96例OLP患者和152例唇炎患者进行了斑贴试验。71例（73.9％）OLP患者和100例（65.8％）唇炎患者记录了一种或多种相关反应。四十三(44.8%),22（22.9%），21名(21.9%)和17名(17.7%)OLP患者对汞相关化学品有相关反应，汞合金,留兰香和香芹,分别,与6（3.9%）相比，3（2.0%），4例（2.6%）和0例（0%）唇炎患者，分别(p值<0.001)。4例(4.2%)OLP患者对焦亚硫酸钠有相关阳性反应,与唇炎组没有相比（p值0.021）。
结论：虽然目前牙科用汞合金的使用频率较低，我们报告说，汞（在汞合金中发现）以及另外的留兰香和香芹酮是澳大利亚OLP中的相关敏化剂。偏亚硫酸氢钠也可能是OLP中的相关敏化剂，以前没有报道过。
目的：我们旨在评估OLP中相关的接触致敏剂。
方法：对2006年1月1日至2020年12月31日在澳大利亚三级皮肤病学机构接受斑贴测试的OLP患者进行了回顾性研究，与同期测试的唇炎患者相比。
结果：在15年期间对96例OLP患者和152例唇炎患者进行了斑贴试验。71例（73.9％）OLP患者和100例（65.8％）唇炎患者记录了一种或多种相关反应。四十三(44.8%),22（22.9%），21名(21.9%)和17名(17.7%)OLP患者对汞相关化学品有相关反应，汞合金,留兰香和香芹,分别,与6（3.9%）相比，3（2.0%），4例（2.6%）和0例（0%）唇炎患者，分别(p值<0.001)。4例(4.2%)OLP患者对焦亚硫酸钠有相关阳性反应,与唇炎组没有相比（p值0.021）。
结论：虽然目前牙科用汞合金的使用频率较低，我们报告说，汞（在汞合金中发现）以及另外的留兰香和香芹酮是澳大利亚OLP中的相关敏化剂。偏亚硫酸氢钠也可能是OLP中的相关敏化剂，以前没有报道过。
