PDF(Pubmed)
Abstract：
Prospective data about quality of life (QoL) in men with breast cancer (BC) are lacking. A prospective registry (EORTC10085) of men with all BC stages, including a QoL correlative study, was performed as part of the International Male Breast Cancer Program.
Questionnaires at BC diagnosis included the EORTC QLQ-C30 and BR23 (BC specific module), adapted for men. High functioning and global health/QoL scores indicate high functioning levels/high QoL; high symptom-focused measures scores indicate high symptoms/problems levels. EORTC reference data for healthy men and women with BC were used for comparisons.
Of 422 men consenting to participate, 363 were evaluable. Median age was 67 years, and median time between diagnosis and survey was 1.1 months. A total of 114 men (45%) had node-positive early disease, and 28 (8%) had advanced disease. Baseline mean global health status score was 73 (SD: 21), better than in female BC reference data (62, SD: 25). Common symptoms in male BC were fatigue (22, SD: 24), insomnia (21, SD: 28), and pain (16, SD: 23), for which women\'s mean scores indicated more burdensome symptoms at 33 (SD: 26), 30 (SD: 32), and 29 (SD: 29). Men\'s mean sexual activity score was 31 (SD: 26), with less sexual activity in older patients or advanced disease.
QoL and symptom burden in male BC patients appears no worse (and possibly better) than that in female patients. Future analyses on impact of treatment on symptoms and QoL over time, may support tailoring of male BC management.
Questionnaires at BC diagnosis included the EORTC QLQ-C30 and BR23 (BC specific module), adapted for men. High functioning and global health/QoL scores indicate high functioning levels/high QoL; high symptom-focused measures scores indicate high symptoms/problems levels. EORTC reference data for healthy men and women with BC were used for comparisons.
Of 422 men consenting to participate, 363 were evaluable. Median age was 67 years, and median time between diagnosis and survey was 1.1 months. A total of 114 men (45%) had node-positive early disease, and 28 (8%) had advanced disease. Baseline mean global health status score was 73 (SD: 21), better than in female BC reference data (62, SD: 25). Common symptoms in male BC were fatigue (22, SD: 24), insomnia (21, SD: 28), and pain (16, SD: 23), for which women\'s mean scores indicated more burdensome symptoms at 33 (SD: 26), 30 (SD: 32), and 29 (SD: 29). Men\'s mean sexual activity score was 31 (SD: 26), with less sexual activity in older patients or advanced disease.
QoL and symptom burden in male BC patients appears no worse (and possibly better) than that in female patients. Future analyses on impact of treatment on symptoms and QoL over time, may support tailoring of male BC management.
摘要：
背景：缺乏关于男性乳腺癌（BC）患者生活质量（QoL）的前瞻性数据。所有BC阶段的男性的前瞻性登记（EORTC10085），包括QoL相关研究，作为国际男性乳腺癌计划的一部分进行。
方法：BC诊断的问卷调查包括EORTCQLQ-C30和BR23（BC特定模块），适应男人。高功能和全球健康/QoL分数表明高功能水平/高QoL;高症状集中测量分数表明高症状/问题水平。健康男性和女性BC的EORTC参考数据用于比较。
结果：422名男性同意参加，363人可评估。年龄中位数是67岁,从诊断到调查的中位时间为1.1个月.共有114名男性（45％）患有淋巴结阳性早期疾病，和28（8％）有晚期疾病。基线平均全球健康状况评分为73分（SD：21），优于女性BC参考数据（62，SD：25）。男性BC的常见症状是疲劳（22，SD：24），失眠（21，SD：28），和疼痛（16，SD：23），女性的平均得分在33岁时显示出更多的负担症状(SD:26)，30（SD：32），和29（SD：29）。男性的平均性活动评分为31（SD：26），老年患者或晚期患者的性活动较少。
结论：男性BC患者的QoL和症状负担没有比女性患者更差（甚至可能更好）。未来对治疗对症状和QoL的影响进行分析，可能支持男性BC管理的剪裁。
方法：BC诊断的问卷调查包括EORTCQLQ-C30和BR23（BC特定模块），适应男人。高功能和全球健康/QoL分数表明高功能水平/高QoL;高症状集中测量分数表明高症状/问题水平。健康男性和女性BC的EORTC参考数据用于比较。
结果：422名男性同意参加，363人可评估。年龄中位数是67岁,从诊断到调查的中位时间为1.1个月.共有114名男性（45％）患有淋巴结阳性早期疾病，和28（8％）有晚期疾病。基线平均全球健康状况评分为73分（SD：21），优于女性BC参考数据（62，SD：25）。男性BC的常见症状是疲劳（22，SD：24），失眠（21，SD：28），和疼痛（16，SD：23），女性的平均得分在33岁时显示出更多的负担症状(SD:26)，30（SD：32），和29（SD：29）。男性的平均性活动评分为31（SD：26），老年患者或晚期患者的性活动较少。
结论：男性BC患者的QoL和症状负担没有比女性患者更差（甚至可能更好）。未来对治疗对症状和QoL的影响进行分析，可能支持男性BC管理的剪裁。
