Abstract：
Cancer is characterized by mutagenic events that lead to disrupted cell signaling and cellular functions. It is one of the leading causes of death worldwide. Literature suggests that pathogens, mainly Helicobacter pylori and Epstein-Barr virus (EBV), have been associated with the etiology of human cancer. Notably, their co-infection may lead to gastric cancer. Pathogen-mediated DNA damage could be the first and crucial step in the carcinogenesis process that modulates numerous cellular signaling pathways. Altogether, it dysregulates the metabolic pathways linked with cell growth, apoptosis, and DNA repair. Modulation in these pathways leads to abnormal growth and proliferation. Several signaling pathways such RTK, RAS/MAPK, PI3K/Akt, NFκB, JAK/STAT, HIF1α, and Wnt/β-catenin are known to be altered in cancer. Therefore, this review focuses on the oncogenic roles of H. pylori, EBV, and its associated signaling cascades in various cancers. Scrutinizing these signaling pathways is crucial and may provide new insights and targets for preventing and treating H. pylori and EBV-associated cancers.
摘要：
癌症的特征在于导致破坏的细胞信号传导和细胞功能的诱变事件。它是全世界死亡的主要原因之一。文献表明病原体，主要是幽门螺杆菌和EB病毒（EBV），已经与人类癌症的病因有关。值得注意的是,它们的共同感染可能导致胃癌。病原体介导的DNA损伤可能是调节许多细胞信号传导途径的致癌过程中的第一步和关键步骤。总之,它失调与细胞生长有关的代谢途径，凋亡，DNA修复这些途径的调节导致异常生长和增殖。几种信号通路，如RTK，RAS/MAPK,PI3K/Akt,NFκB,JAK/STAT,HIF1α,已知Wnt/β-连环蛋白在癌症中发生改变。因此,这篇综述集中在幽门螺杆菌的致癌作用，EBV,及其在各种癌症中的相关信号级联。仔细研究这些信号通路至关重要，可能为预防和治疗幽门螺杆菌和EBV相关癌症提供新的见解和靶标。
