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Abstract：
Psoriasis is a chronic inflammatory skin disease characterized by skin infiltration of immune cells and abnormal epidermal thickening. The initial pathogenesis has not been fully elucidated. Non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs) and circular RNAs (circRNAs), comprise the majority of genome transcripts and are important influencers of gene transcription and post-transcription modulations. Emerging roles of ncRNAs in psoriasis were identified recently. This review summarizes the existing studies of psoriasis-related lncRNAs and circRNAs. A considerable proportion of the studied lncRNAs and circRNAs regulate keratinocyte mobility, such as keratinocyte proliferation and differentiation. Some lncRNAs and circRNAs are tightly related to keratinocyte inflammation reactions. Other reports demonstrated that they are also implicated in modulating immune cell differentiation, proliferation, and activation. This review might illuminate future psoriasis research and highlight that lncRNAs and circRNAs might act as therapeutic targets.
摘要：
银屑病是一种以免疫细胞浸润和表皮异常增厚为特征的慢性炎症性皮肤病。最初的发病机制尚未完全阐明。非编码RNA（ncRNAs），其中包括长ncRNAs（lncRNAs）和环状RNAs（circRNAs），包含大多数基因组转录本，并且是基因转录和转录后调节的重要影响者。最近发现了ncRNAs在银屑病中的新兴作用。本文综述了银屑病相关lncRNAs和circRNAs的现有研究。相当比例的研究lncRNAs和circRNAs调节角质形成细胞的迁移率，如角质形成细胞的增殖和分化。一些lncRNAs和circRNAs与角质形成细胞炎症反应密切相关。其他报道表明，它们也参与调节免疫细胞分化，扩散,和激活。这篇综述可能会阐明未来的银屑病研究，并强调lncRNAs和circRNAs可能作为治疗靶标。
