PDF(Pubmed)
Abstract：
BACKGROUND: Pancreatic endocrine insufficiency is more likely to occur after acute pancreatitis (AP), but the risk factors affecting pancreatic endocrine function remain controversial. Therefore, exploring the incidence and risk factors of fasting hyperglycaemia following first-attack AP is important.
METHODS: Data were collected from 311 individuals with first-attack AP without previous diabetes mellitus (DM) or impaired fasting glucose (IFG) history treated in the Renmin Hospital of Wuhan University. Relevant statistical tests were performed. A two-sided p-value < 0.05 was considered statistically significant.
RESULTS: The incidence of fasting hyperglycaemia in individuals with first-attack AP was 45.3%. Univariate analysis showed that age (χ2 = 6.27, P = 0.012), aetiology (χ2 = 11.184, P = 0.004), serum total cholesterol (TC) (χ2 = 14.622, P < 0.001), and serum triglyceride (TG) (χ2 = 15.006, P < 0.001) were significantly different between the hyperglycaemia and non-hyperglycaemia groups (P < 0.05). The serum calcium concentration (Z=-2.480, P = 0.013) was significantly different between the two groups (P < 0.05). Multiple logistic regression analysis showed that age- ≥60 years (P < 0.001, OR = 2.631, 95%Cl = 1.529-4.527) and TG ≥ 5.65 mmol/L (P < 0.001, OR = 3.964, 95%Cl = 1.990-7.895) were independent risk factors for fasting hyperglycaemia in individuals with first-attack AP (P < 0.05).
CONCLUSIONS: Old age, serum triglycerides, serum total cholesterol, hypocalcaemia, and aetiology are associated with fasting hyperglycaemia following first-attack AP. Age ≥ 60 years and TG ≥ 5.65 mmol/L are independent risk factors for fasting hyperglycaemia following first-attack AP.
METHODS: Data were collected from 311 individuals with first-attack AP without previous diabetes mellitus (DM) or impaired fasting glucose (IFG) history treated in the Renmin Hospital of Wuhan University. Relevant statistical tests were performed. A two-sided p-value < 0.05 was considered statistically significant.
RESULTS: The incidence of fasting hyperglycaemia in individuals with first-attack AP was 45.3%. Univariate analysis showed that age (χ2 = 6.27, P = 0.012), aetiology (χ2 = 11.184, P = 0.004), serum total cholesterol (TC) (χ2 = 14.622, P < 0.001), and serum triglyceride (TG) (χ2 = 15.006, P < 0.001) were significantly different between the hyperglycaemia and non-hyperglycaemia groups (P < 0.05). The serum calcium concentration (Z=-2.480, P = 0.013) was significantly different between the two groups (P < 0.05). Multiple logistic regression analysis showed that age- ≥60 years (P < 0.001, OR = 2.631, 95%Cl = 1.529-4.527) and TG ≥ 5.65 mmol/L (P < 0.001, OR = 3.964, 95%Cl = 1.990-7.895) were independent risk factors for fasting hyperglycaemia in individuals with first-attack AP (P < 0.05).
CONCLUSIONS: Old age, serum triglycerides, serum total cholesterol, hypocalcaemia, and aetiology are associated with fasting hyperglycaemia following first-attack AP. Age ≥ 60 years and TG ≥ 5.65 mmol/L are independent risk factors for fasting hyperglycaemia following first-attack AP.
摘要：
背景：急性胰腺炎（AP）后更容易发生胰腺内分泌功能不全，但影响胰腺内分泌功能的危险因素仍存在争议。因此,探讨首次发作AP后空腹高血糖的发生率和危险因素非常重要。
方法：收集在武汉大学人民医院接受治疗的311例初发AP患者的数据，这些患者没有既往糖尿病（DM）或空腹血糖受损（IFG）病史。进行相关统计检验。双侧P值<0.05被认为是统计学上显著的。
结果：首次发作AP患者空腹高血糖的发生率为45.3%。单因素分析显示年龄(χ2=6.27,P=0.012),病因（χ2=11.184，P=0.004），血清总胆固醇(TC)(χ2=14.622,P<0.001),高血糖组和非高血糖组之间的血清甘油三酯（TG）（χ2=15.006，P<0.001）差异有统计学意义（P<0.05）。两组血清钙浓度差异有统计学意义(Z=-2.480,P=0.013)(P<0.05)。多因素logistic回归分析显示，年龄≥60岁（P<0.001，OR=2.631，95％Cl=1.529-4.527）和TG≥5.65mmol/L（P<0.001，OR=3.964，95％Cl=1.990-7.895）是初发AP患者空腹高血糖的独立危险因素（P<0.05）。
结论：老年，血清甘油三酯，血清总胆固醇,低钙血症,病因学与首次发作AP后空腹高血糖有关。年龄≥60岁和TG≥5.65mmol/L是首次发作AP后空腹高血糖的独立危险因素。
方法：收集在武汉大学人民医院接受治疗的311例初发AP患者的数据，这些患者没有既往糖尿病（DM）或空腹血糖受损（IFG）病史。进行相关统计检验。双侧P值<0.05被认为是统计学上显著的。
结果：首次发作AP患者空腹高血糖的发生率为45.3%。单因素分析显示年龄(χ2=6.27,P=0.012),病因（χ2=11.184，P=0.004），血清总胆固醇(TC)(χ2=14.622,P<0.001),高血糖组和非高血糖组之间的血清甘油三酯（TG）（χ2=15.006，P<0.001）差异有统计学意义（P<0.05）。两组血清钙浓度差异有统计学意义(Z=-2.480,P=0.013)(P<0.05)。多因素logistic回归分析显示，年龄≥60岁（P<0.001，OR=2.631，95％Cl=1.529-4.527）和TG≥5.65mmol/L（P<0.001，OR=3.964，95％Cl=1.990-7.895）是初发AP患者空腹高血糖的独立危险因素（P<0.05）。
结论：老年，血清甘油三酯，血清总胆固醇,低钙血症,病因学与首次发作AP后空腹高血糖有关。年龄≥60岁和TG≥5.65mmol/L是首次发作AP后空腹高血糖的独立危险因素。
