Abstract：
OBJECTIVE: The \"collapse,\" a highly flexed, dented, or caved membrane between the endo- and peri-lymph of the saccule and utricle in adults, is considered as a morphological aspect of Ménière\'s syndrome. Likewise, when mesh-like tissues in the perilymphatic space are damaged or lost, the endothelium loses mechanical support and causes nerve irritation. However, these morphologies were not examined in fetuses.
METHODS: By using histological sections from 25 human fetuses (crown-rump length[CRL] 82-372 mm; approximately 12-40 weeks), morphologies of the perilymphatic-endolymphatic border membrane and the mesh-like tissue around the endothelium were examined.
RESULTS: The highly flexed or caved membrane between the endo- and peri-lymphatic spaces was usually seen in the growing saccule and utricle of fetuses, especially at junctions between the utricle and ampulla at midterm. Likewise, the perilymphatic space around the saccule, utricle and semicircular ducts often lost the mesh-like tissues. The residual mesh-like tissue supported the veins, especially in the semicircular canal.
CONCLUSIONS: Within a cartilaginous or bony room showing a limited growth in size but containing increased perilymph, the growing endothelium appeared to become wavy. Owing to a difference in growth rates between the utricle and semicircular duct, the dentation tended to be more frequently seen at junctions than at free margins of the utricle. The difference in site and gestational age suggested that the deformity was not \"pathological\" but occurred due to unbalanced growth of the border membrane. Nevertheless, the possibility that the deformed membrane in fetuses was an artifact caused by delayed fixation is not deniable.
METHODS: By using histological sections from 25 human fetuses (crown-rump length[CRL] 82-372 mm; approximately 12-40 weeks), morphologies of the perilymphatic-endolymphatic border membrane and the mesh-like tissue around the endothelium were examined.
RESULTS: The highly flexed or caved membrane between the endo- and peri-lymphatic spaces was usually seen in the growing saccule and utricle of fetuses, especially at junctions between the utricle and ampulla at midterm. Likewise, the perilymphatic space around the saccule, utricle and semicircular ducts often lost the mesh-like tissues. The residual mesh-like tissue supported the veins, especially in the semicircular canal.
CONCLUSIONS: Within a cartilaginous or bony room showing a limited growth in size but containing increased perilymph, the growing endothelium appeared to become wavy. Owing to a difference in growth rates between the utricle and semicircular duct, the dentation tended to be more frequently seen at junctions than at free margins of the utricle. The difference in site and gestational age suggested that the deformity was not \"pathological\" but occurred due to unbalanced growth of the border membrane. Nevertheless, the possibility that the deformed membrane in fetuses was an artifact caused by delayed fixation is not deniable.
摘要：
目标：“崩溃，“一个高度弯曲的，凹陷,或成人囊和囊的淋巴内和周淋巴之间的凹陷膜，被认为是梅尼埃综合征的形态学方面。同样，当淋巴外空间的网状组织受损或丢失时，内皮失去机械支持并引起神经刺激。然而,这些形态未在胎儿中检查。
方法：通过使用来自25个人类胎儿的组织学切片（冠部长度[CRL]82-372毫米；大约12-40周），检查了外淋巴-内淋巴边界膜和内皮周围网状组织的形态。
结果：通常在胎儿正在生长的囊和外囊中可以看到内淋巴空间和周围淋巴空间之间高度弯曲或凹陷的膜，特别是在中期的囊骨和壶腹之间的交界处。同样，球囊周围的淋巴空间，胞囊和半圆形导管经常失去网状组织。残留的网状组织支撑着静脉，尤其是在半规管中。
结论：在软骨或骨室内，显示出有限的生长，但含有增加的外淋巴液，生长的内皮似乎变得波浪状。由于胞囊和半圆形管之间的生长速率不同，在接头处比在小骨的自由边缘更容易看到凹陷。部位和胎龄的差异表明畸形不是“病理性的”，而是由于边界膜的不平衡生长而发生的。然而，胎儿的膜变形是由延迟固定引起的伪影的可能性是不可否认的。
方法：通过使用来自25个人类胎儿的组织学切片（冠部长度[CRL]82-372毫米；大约12-40周），检查了外淋巴-内淋巴边界膜和内皮周围网状组织的形态。
结果：通常在胎儿正在生长的囊和外囊中可以看到内淋巴空间和周围淋巴空间之间高度弯曲或凹陷的膜，特别是在中期的囊骨和壶腹之间的交界处。同样，球囊周围的淋巴空间，胞囊和半圆形导管经常失去网状组织。残留的网状组织支撑着静脉，尤其是在半规管中。
结论：在软骨或骨室内，显示出有限的生长，但含有增加的外淋巴液，生长的内皮似乎变得波浪状。由于胞囊和半圆形管之间的生长速率不同，在接头处比在小骨的自由边缘更容易看到凹陷。部位和胎龄的差异表明畸形不是“病理性的”，而是由于边界膜的不平衡生长而发生的。然而，胎儿的膜变形是由延迟固定引起的伪影的可能性是不可否认的。
