Abstract：
Candidiasis is an infection caused by fungi from a Candida species, most commonly Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on human skin and mucous membranes of the mouth, intestines or vagina. It can cause a wide variety of mucocutaneous barrier and systemic infections; and becomes a severe health problem in HIV/AIDS patients and in individuals who are immunocompromised following chemotherapy, treatment with immunosuppressive agents or after antibiotic-induced dysbiosis. However, the immune mechanism of host resistance to C. albicans infection is not fully understood, there are a limited number of therapeutic antifungal drugs for candidiasis, and these have disadvantages that limit their clinical application. Therefore, it is urgent to uncover the immune mechanisms of the host protecting against candidiasis and to develop new antifungal strategies. This review synthesizes current knowledge of host immune defense mechanisms from cutaneous candidiasis to invasive C. albicans infection and documents promising insights for treating candidiasis through inhibitors of potential antifungal target proteins.
摘要：
念珠菌病是由念珠菌属真菌引起的感染，最常见的白色念珠菌。白色念珠菌是一种机会性真菌病原体，通常存在于人类皮肤和口腔粘膜上，肠或阴道。它可以引起各种各样的粘膜皮肤屏障和全身感染;并成为艾滋病毒/艾滋病患者和化疗后免疫功能低下的个体的严重健康问题。用免疫抑制剂治疗或抗生素诱导的菌群失调后。然而,宿主对白色念珠菌感染耐药的免疫机制尚未完全了解，念珠菌病的治疗性抗真菌药物数量有限，这些缺点限制了它们的临床应用。因此,迫切需要揭示宿主预防念珠菌病的免疫机制，并开发新的抗真菌策略。这篇综述综合了从皮肤念珠菌病到侵袭性白色念珠菌感染的宿主免疫防御机制的最新知识，并记录了通过潜在抗真菌靶蛋白抑制剂治疗念珠菌病的有希望的见解。
