PDF(Pubmed)
Abstract：
Fungal species have dynamic genomes and often exhibit genomic plasticity in response to stress. This genome plasticity often comes with phenotypic consequences that affect fitness and resistance to stress. Fungal pathogens exhibit genome plasticity in both clinical and agricultural settings and often during adaptation to antifungal drugs, posing significant challenges to human health. Therefore, it is important to understand the rates, mechanisms, and impact of large genomic changes. This review addresses the prevalence of polyploidy, aneuploidy, and copy number variation across diverse fungal species, with special attention to prominent fungal pathogens and model species. We also explore the relationship between environmental stress and rates of genomic changes and highlight the mechanisms underlying genotypic and phenotypic changes. A comprehensive understanding of these dynamic fungal genomes is needed to identify novel solutions for the increase in antifungal drug resistance.
摘要：
真菌物种具有动态的基因组，并且通常在响应胁迫时表现出基因组可塑性。这种基因组可塑性通常伴随着影响适应性和对压力的抵抗力的表型后果。真菌病原体在临床和农业环境中表现出基因组可塑性，并且通常在适应抗真菌药物期间。对人类健康构成重大挑战。因此,了解利率很重要，机制,以及大的基因组变化的影响。这篇综述讨论了多倍体的普遍性，非整倍体,和不同真菌物种的拷贝数变异，特别注意突出的真菌病原体和模型物种。我们还探讨了环境压力与基因组变化率之间的关系，并强调了基因型和表型变化的潜在机制。需要全面了解这些动态真菌基因组，以确定增加抗真菌药物抗性的新解决方案。微生物学年度评论的预期最终在线出版日期，第77卷是2023年9月。请参阅http://www。annualreviews.org/page/journal/pubdates的订正估计数。
