Abstract：
The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam - nicotin-amide, Gly - glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87-5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions -16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.
摘要：
这项研究的目的是评估抗菌活性，用合成银（I）配合物制备的乳膏（浓度为1％）的质量和稳定性：[Ag（Nam）2]NO3·H2O（AgNam），[Ag2(HGly)2]n(NO3)2n(AgGly)(Nam-烟酰胺,甘氨酸）和银（I）磺胺嘧啶（AgSD），这是商业上可用的。通过琼脂孔扩散法和体内情况评价抗菌活性。纯银（I）配合物以及所有三种装有AgGly的测试面霜，AgSD和AgNam显示出抗菌潜力。此外，负载有AgGly和AgNam的乳膏显示出比负载有AgSD的乳膏更高的对金黄色葡萄球菌和枯草芽孢杆菌的抗菌作用。在外观上,所有奶油样品都是不透明无味的，并且没有观察到相分离。乳膏可溶于水(o/w乳液)并且它们具有假塑性行为。乳膏的pH在4.87-5.75的范围内。在商业使用的AgSD乳膏的情况下,在-16±1°C;6±1°C和56%相对湿度;20±1°C和58%相对湿度以及40±1°C和75%相对湿度的条件下,在一个月测试期间没有观察到可见的变化。然而,含有AgGly和AgNam的面霜根据测试条件改变其颜色。
