关键词: 99mTc-DMSA Acquisition Pediatric Preset count Renal

Mesh : Child Humans Technetium Tc 99m Dimercaptosuccinic Acid Radionuclide Imaging Kidney / diagnostic imaging Regression Analysis Biological Transport Radiopharmaceuticals

来  源:   DOI:10.1007/s12149-023-01849-6

Abstract:
OBJECTIVE: This study was aimed at determining the minimum acquisition count to provide diagnosable image quality (DIQ) and investigating the usefulness of preset count acquisition (PCA) for planar images of pediatric 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy.
METHODS: First, we calculated a coefficient of variation (CV) for DIQ with the shortest acquisition time through visual evaluation in 12 pediatric patients who underwent 99mTc-DMSA scintigraphy. Second, a minimum acquisition count to achieve the CV for DIQ was determined with the single regression analysis using CV as an explanatory variable and the total acquisition count as an objective variable in 81 pediatric patients. Finally, we compared PCA images based on the minimum acquisition count and preset time acquisition (PTA) images for 5 min in terms of the acquisition time, CV, and renal uptake ratio in another 23 pediatric patients.
RESULTS: The visual evaluation showed that the CV corresponding to DIQ with the shortest acquisition time was 27.1%. The total acquisition count corresponding to DIQ was revealed to be 299,764 in the single regression analysis and was determined to be 300,000 after rounding. The CV and its standard deviation in PCA at 300,000 counts and PTA for 5 min were 26.4 ± 0.6% and 24.8 ± 1.3%, respectively. The standard deviation of CV in PCA at 300,000 counts was smaller than that in PTA for 5 min, indicating little variation in image quality between cases. The acquisition time in PCA at 300,000 counts (3.1 ± 0.7 min) was shorter than that in PTA for 5 min (5.0 ± 0.0 min). The intraclass correlation coefficient between renal uptake ratios for PCA and PTA was 0.98, indicating an extremely high concordance.
CONCLUSIONS: The minimum acquisition count required for the DIQ was 300,000. In addition, PCA at 300,000 counts was demonstrated to be useful by providing stable image quality at the shortest acquisition time.
摘要:
目的:本研究旨在确定最小采集计数以提供可诊断的图像质量(DIQ),并研究预设计数采集(PCA)对小儿99mTc-二巯基琥珀酸(DMSA)闪烁显像的平面图像的有用性。
方法:首先,我们在12例接受99mTc-DMSA闪烁显像的儿科患者中,通过视觉评估,以最短的采集时间计算了DIQ的变异系数(CV).第二,在81例儿科患者中,通过单一回归分析,以CV作为解释变量,以总采集计数作为客观变量,确定达到DIQCV的最小采集计数.最后,我们比较了基于最小采集计数的PCA图像和预设时间采集(PTA)图像5分钟的采集时间,CV,和肾脏摄取率在另外23名儿科患者。
结果:视觉评估表明,获取时间最短的DIQ对应的CV为27.1%。在单项回归分析中,DIQ对应的总采集计数为299,764,四舍五入后确定为30万。在300,000计数的PCA和5分钟的PTA中的CV及其标准偏差分别为26.4±0.6%和24.8±1.3%,分别。PCA在300,000计数时的CV标准偏差小于PTA5分钟的CV标准偏差,表明病例之间的图像质量变化很小。PCA在300,000计数下的采集时间(3.1±0.7分钟)短于PTA中的采集时间5分钟(5.0±0.0分钟)。PCA和PTA的肾脏摄取比之间的组内相关系数为0.98,表明非常高的一致性。
结论:DIQ所需的最小采集计数为300,000。此外,通过在最短的采集时间内提供稳定的图像质量,证明了300,000计数的PCA是有用的。
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