PDF(Pubmed)
Abstract：
Benzodiazepines (BDZs) are used in clinics for anxiolysis, anticonvulsants, sedative hypnosis, and muscle relaxation. They have high consumptions worldwide because of their easy availability and potential addiction. They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault. The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging. Efficient pretreatment methods followed by accurate and sensitive detections are necessary. Herein, pretreatment methods for the extraction, enrichment, and preconcentration of BDZs as well as the strategies for their screening, identification, and quantitation developed in the past five years have been reviewed. Moreover, recent advances in various methods are summarized. Characteristics and advantages of each method are encompassed. Future directions of the pretreatment and detection methods for BDZs are also reviewed.
摘要：
苯二氮卓类药物（BDZs）用于临床抗焦虑，抗惊厥药,镇静催眠,肌肉放松。由于容易获得和潜在的成瘾，它们在全球范围内的消费量很高。它们通常用于自杀或犯罪行为，例如绑架和毒品促进的性侵犯。使用小剂量BDZs的药理作用及其从复杂生物基质中的检测是具有挑战性的。需要有效的预处理方法，然后进行准确和灵敏的检测。在这里，提取的预处理方法，富集,和BDZ的预浓缩以及它们的筛选策略，identification,并对过去五年发展的定量进行了回顾。此外，总结了各种方法的最新进展。涵盖了每种方法的特征和优点。还回顾了BDZs的预处理和检测方法的未来方向。
