PDF(Pubmed)
Abstract：
For a long time, the uterus had been considered a sterile organ, meaning that under physiological conditions the uterus would not be colonized by bacteria. Based on available data, it may be concluded that the gut and uterine microbiome are related, and that the role of this microbiome is greater than expected. Despite being the most common pelvic neoplasms in women of reproductive age, uterine fibroids (UFs) are still poorly understood tumors whose etiology has not been fully determined. This systematic review presents the relationship between intestinal and uterine dysbiosis and uterine fibroids. A systematic review of three medical databases was carried out: the MEDLINE/PubMed, Scopus and Cochrane. In this study, 195 titles and abstracts were reviewed, including only original articles and clinical trials of uterine microbiome criteria. Finally, 16 studies were included to the analysis. In recent years, researchers dealing with reproduction in a broad sense have focused on the microbiome in various locations to study its role in the pathogenesis and, consequently, the prevention and treatment of diseases of the genital organ. Conventional microbial detection methods are not suitable for identifying bacteria, which are difficult to culture. Next-generation sequencing (NGS) provides an easier and faster and more informative analysis of bacterial populations. It seems that gut microbiota dysbiosis has the potential to be a risk factor for uterine fibroids or affect the disease process. Some changes were shown in many types of bacteria, such as Firmicutes, Proteobacteria, Actinobacteria and Verrucomicrobia detected in fecal samples in patients with uterine fibroids. In view of the few results on the link between the microbiome and uterine fibroids, further intensive studies in humans and animal models are necessary, including the possible use of different microbiome modulations in the prevention or treatment of uterine fibroids.
摘要：
很长一段时间,子宫被认为是无菌器官,这意味着在生理条件下，子宫不会被细菌定植。根据现有数据，可以得出结论，肠道和子宫微生物群是相关的，而且这种微生物组的作用比预期的要大。尽管是育龄妇女中最常见的盆腔肿瘤，子宫肌瘤（UFs）仍然是人们对其病因尚未完全确定的肿瘤知之甚少。本系统综述了肠道和子宫菌群失调与子宫肌瘤之间的关系。对三个医学数据库进行了系统评价：MEDLINE/PubMed，Scopus和Cochrane.在这项研究中,审查了195份标题和摘要，仅包括子宫微生物组标准的原始文章和临床试验。最后,16项研究纳入分析。近年来,从广义上讲，研究生殖的研究人员集中在不同位置的微生物组以研究其在发病机理中的作用，因此,生殖器官疾病的预防和治疗。常规的微生物检测方法不适用于细菌的鉴别,很难培养。下一代测序（NGS）提供了更容易，更快速和更多信息的细菌种群分析。肠道菌群失调似乎有可能成为子宫肌瘤的危险因素或影响疾病过程。在许多类型的细菌中显示出一些变化，比如Firmicutes，变形杆菌,在子宫肌瘤患者的粪便样本中检测到的放线菌和Verrucomicrobia。鉴于微生物组和子宫肌瘤之间的联系的结果很少，在人类和动物模型的进一步深入研究是必要的，包括在子宫肌瘤的预防或治疗中可能使用不同的微生物组调节。
